消癥杀胚煎剂治疗未破裂型输卵管异位妊娠的疗效及对产妇卵巢功能、生育结局的影响

Efficacy of xiaozhengshapei decoction in treating unruptured tubal ectopic pregnancy and its effect on maternal ovary function and fertility outcome

目的消癥杀胚煎剂治疗未破裂型输卵管异位妊娠的疗效及对产妇卵巢功能、生育结局的影响。方法选择2015年9月至2017年9月荆门市第二人民医院接诊的74例未破裂型输卵管异位妊娠患者,按随机数表法分为观察组及对照组各37。对照组使用抑那通进行治疗,观察组在此基础上,加用消癥杀胚煎剂进行治疗。比较两组的卵泡刺激素(FSH)、雌二醇(E2)、促黄体生成素(LH)、抗子宫内膜抗体(EMAb)。结果治疗后,观察组FSH、LH水平低于对照组[(20. 44±1. 74) U/Lvs (28. 55±1. 93) U/L,(21. 28±2. 13) U/L vs(25. 25±2. 18) U/L],差异具有统计学意义(P <0. 05);观察组E2水平高于对照组[(250. 12±7. 77) pmol/L vs(174. 78±8. 16) pmol/L](P <0. 05);观察组血清EMAb阳性率低于对照组[10(27. 03%) vs 22(59. 46%)],差异具有统计学意义(P <0. 05);经治疗2周后,观察组的血清β-HCG、孕酮水平明显低于对照组,差异具有统计学意义(P <0. 05),正常妊娠率明显高于对照,差异具有统计学意义(P <0. 05)。结论消癥杀胚煎剂联合抑那通治疗未破裂型输卵管异位妊娠可有效改善内异症患者卵巢功能,疗效安全可靠,值得应用推广。

Objective To study the efficacy of xiaozhengshapei decoction in treating unruptured tubal ectopic pregnancy and its effect on maternal ovary function and fertility outcome.Methods 74 patients with unruptured tubal ectopic pregnancy admitted into our hospital from September 2015 to September 2017 were divided into observation group and control group according to random number table method.The control group was treated with enantone.The observation group was treated with xiaozhengshapei decoction and enantone.The follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH)and anti-endometrial antibodies(EAMb)of the two groups were compared.Results After treatment,the levels of FSH and LH in observation group were lower than those in control group[(20.44±1.74)U/L vs(28.55±1.93)U/L,(21.28±2.13)U/L vs(25.25±2.18)U/L](P<0.05).The levels of E2 in observation group were higher than those in control group[(250.12±7.77)pmol/L vs(174.78±8.16)pmol/L](P<0.05).The positive rate of serum EMAb in observation group was lower than that in control group[10(27.03%)vs 22(59.46%)](P<0.05).Conclusions Xiaozhengshapei decoction combined with enantone in the treatment of unruptured tubal ectopic pregnancy can effectively improve the ovarian function of patients,safe and reliable,which is worthy of promotion.