甲泼尼龙治疗小儿难治性肺炎支原体肺炎的临床疗效分析

Clinical Analysis of Methylprednisolone in Treatment of Refractory Mycoplasma Pneumoniae Pneumonia in Children

目的探究甲泼尼龙在小儿难治性肺炎支原体肺炎治疗中的应用价值。方法选取2014年4月—2018年1月间海口市秀英区海秀卫生院收治的85例小儿难治性肺炎支原体肺炎患儿为研究对象,按照随机数字表法分为两组,对照组采用阿奇霉素抗支原体等常规治疗,在此基础上研究组给予甲泼尼龙治疗,对比两组患儿退热时间、咳嗽缓解时间、C-反应蛋白(CRP)改善情况、治疗总有效率情况等。结果对照组退热时间、咳嗽缓解时间明显高于研究组,差异有统计学意义(P<0.05);两组患儿治疗后的CRP水平明显低于治疗前,且研究组明显低于对照组,差异有统计学意义(P<0.05);对照组患儿治疗总有效率为78.57%,明显低于研究组的95.35%,差异有统计学意义(P<0.05)。结论小儿难治性肺炎支原体肺炎治疗中联合使用甲泼尼龙,有助于缩短病程、症状改善见效快,抗炎效果突出,有助于提升治疗总有效率。

Objective To explore the application value of methylprednisolone in the treatment of refractory Mycoplasma pneumo. nia in children. Methods 85 children with refractory Mycoplasma pneumoniae pneumonia from April,2014 to January,2018,were selected as subjects. The control group were treated with routine treatment such as azithromycin antimycoplasma,and the study group were treated with methylprednisolone. The fever time,cough relief time,CRP improvement and total effective rate were compared be. tween the two groups. Results Fever time and cough relief time in control group were significantly higher than the study group,and the difference was significant(P<0.05). The CRP level of the two groups after treatment was significantly lower than that before treat. ment,and the study group was significantly lower than that of the control group(P<0.05). The total effective rate of the control group was 78.57%,which was significantly lower than 95.35% of the study group. There was statistically significant difference(P<0.05). Conclusion The combination of methylprednisolone in the treatment of refractory Mycoplasma pneumoniae pneumonia in children can shorten the course of disease,improve symptoms quickly,have outstanding anti-inflammatory effect,and improve the total effective rate of treatment.