综合营养干预对晚期大肠癌化疗患者营养状况及生存质量的影响

The effect of comprehensive nutritional intervention on the nutritional status and quality of life of advanced colorectal cancer patients undergoing chemotherapy

目的:探讨综合营养干预对晚期大肠癌化疗患者营养状况及生存质量的影响。方法:选择晚期大肠癌患者100例,随机分为对照组和观察组各50例,对照组给予常规饮食,观察组在常规饮食基础上给予个体化膳食指导、教育及肠内肠外营养治疗等综合营养干预,对比治疗前后两组患者近期疗效、营养状况、免疫功能、生存质量及治疗依从性等结果变化。结果:经综合营养干预后,两组化疗有效率与毒副反应比较,差异均无统计学意义(P> 0. 05);观察组在营养状况、免疫功能、生存质量及治疗依从性等方面优于对照组(P <0. 05),差异有统计学意义。结论:综合营养干预可有效改善晚期大肠癌化疗患者的营养状况、免疫功能、生存质量及治疗依从性,效果明显,值得临床推广应用。

Objective:To investigate the effect of comprehensive nutritional intervention on the nutritional status and life quality of patients with advanced colorectal cancer underwent chemotherapy.Methods:A total of 100 patients with advanced colorectal cancer were randomly divided into 2 groups,including the control group and the observation group,with 50 cases in each group.Patients in the control group were treated with a regular diet,while patients in the observation group were treated with extra personalized dietary guidance,education,enteral and parenteral nutritional therapy and other nutritional interventions.The short-term efficacy,nutritional status,immune function,life quality,and treatment compliance before and after treatment were compared between the two groups.Results:After comprehensive nutritional interventions,there was no significant difference between the two groups in the efficacy of chemotherapy and side effects(P>0.05).The observation group was better than the control group in terms of nutritional status,immune function,life quality,and treatment compliance(P<0.05),and the difference was statistically significant.Conclusion:Comprehensive nutritional interventions can effectively improve the nutritional status,immune function,quality of life,and treatment compliance of patients with advanced colorectal cancer underwent chemotherapy.The effect is obvious and worthy of clinical application.