恶性肿瘤特异生长因子和肿瘤浸润性树突状细胞在子宫内膜癌患者中的表达及临床意义

Expression and significance of tumor specific growth factor and tumor infiltrating dendritic cells in patients with endometrial carcinoma

目的:探讨恶性肿瘤特异生长因子(TSFG)和肿瘤浸润性树突状细胞(TIDC)在子宫内膜癌患者中的表达及临床意义。方法:选择2015年1月至2017年1月我院收治的子宫内膜癌患者50例。检测子宫内膜组织中TIDC和血清中TSFG水平,分析TSFG、TIDC在不同临床病理特征患者中的表达。结果:与癌旁组织比较,肿瘤组织中TIDC明显降低(P=0. 000); MHC-Ⅱ阳性树突状细胞(DC)(%)明显降低(P=0. 000);CD54阳性DC(%)明显降低(P=0. 000)。与非淋巴结转移的患者相比,淋巴结转移的患者TIDC、MHC-Ⅱ阳性DC(%)、CD54阳性DC(%)均明显降低,TSFG明显增高(P <0. 05)。与临床TNM分期为Ⅰ或Ⅱ期的患者相比,Ⅲ或Ⅳ期的患者TIDC、MHC-Ⅱ阳性DC(%)和CD54阳性DC(%)均明显降低,TSFG明显增高(P<0. 05)。与肌层浸润≤1/2的患者相比,肌层浸润> 1/2的患者TIDC、MHC-Ⅱ阳性DC(%)和CD54阳性DC(%)均明显降低,TSFG明显增高(P <0. 05)。与中、高分化的患者相比,低分化患者组织中TIDC、MHC-Ⅱ阳性DC(%)和CD54阳性DC(%)均明显降低,TSFG明显增高(P <0. 05)。结论:TIDC在肿瘤组织中低表达,且多为不成熟的调节性DC细胞。低分化、TNM分期为Ⅲ或Ⅳ期、淋巴结发生转移、肌层浸润> 1/2的患者血清中TSFG水平明显升高,而肿瘤组织中TIDC明显降低。提示子宫内膜癌患者血清中TSFG和肿瘤组织中TIDC可作为判断预后的指标。

Objective:To investigate the expression and significance of tumor specific growth factor(TSFG)and tumor infiltrating dendritic cell(TIDC)in patients with endometrial carcinoma.Methods:From January 2015 to January 2017,we prospectively collected 50 patients with endometrial carcinoma in our hospital.The levels of TIDC in endometrial tissues and serum TSFG were detected,and the correlation between TSFG,TIDC and clinical features of the patients was analyzed.Results:When compared with adjacent tissues,tumor tissues got a reduced TIDC(P=0.000),a lower percentage of MHC-Ⅱpositive DC(%)(P=0.000),and a reduce in CD54 positive DC(%)(P=0.000).When compared with patients without lymph node metastasis,TIDC,MHC-Ⅱpositive DC(%),CD54 positive DC(%)in patients with lymph node metastasis were significantly lower,and TSFG increased significantly(P<0.05).When compared with patients withⅠorⅡof TNM stage,TIDC,MHC-Ⅱpositive DC(%)and CD54 positive DC(%)decreased significantly in patients with stageⅢorⅣ,and TSFG increased significantly(P<0.05).When compared with the myometrial invasion≤1/2 patients,TIDC,MHC-Ⅱpositive DC(%)and CD54 positive DC(%)were significantly decreased in myometrial invasion>1/2 patients,TSFG significantly increased(P<0.05).When compared with patients with moderate and high differentiated patients,TIDC,MHC-Ⅱpositive DC(%)and CD54 positive DC(%)were significantly decreased in poorly differentiated,and TSFG increased significatly(P<0.05).Conclusion:The expression of TIDC in tumor tissues is low,and most of them are immature regulatory DC cells.In the patients with poorly differentiated,stageⅢorⅣ,lymph node metastasis,the level of serum TSFG in patients with myometrial infiltration>1/2 were increased significantly,and TIDC were decreased significantly.The results suggest that serum TSFG and TIDC in tumor tissue can be used as prognostic indicators.