奥施康定联合塞来昔布治疗妇科恶性肿瘤中重度疼痛的疗效观察

Therapeutic effect of OxyContin combined with Celecoxib in treating pain of gynecologic tumors

目的:观察奥施康定联合塞来昔布治疗妇科恶性肿瘤中重度疼痛的临床疗效。方法:选取我院收治的79例妇科中重度癌痛患者作为研究对象,随机分为两组,对照组患者(n=33)在一般治疗的基础上加用奥施康定进行镇痛,观察组患者(n=46)在此基础上加用塞来昔布进行镇痛。统计分析两组患者镇痛效果、5-羟色胺(5-HT)、去甲肾上腺素(NE)水平及不良反应。结果:经过治疗后,观察组患者NRS评分低于对照组患者,观察组患者治疗有效缓解率高于对照组患者,观察组患者5-HT、NE水平均低于对照组患者,差异具有统计学意义(P <0. 05);观察组患者便秘发生率低于对照组患者,差异具有统计学意义(P <0. 05)。结论:奥施康定联合塞来昔布治疗妇科恶性肿瘤中重度疼痛具有确切的效果,可降低单纯应用奥施康定的不良反应,值得临床推广。

Objective:To observe the clinical efficacy of OxyContin combined with Celecoxib in the treatment of pain of gynecologic tumors.Methods:A total of 79 patients with gynecologic cancer pain admitted to our hospital were selected as study subjects and randomly divided into two groups.The patients in the control group(n=33)were treated with OxyContin on the basis of general treatment.The patients in the observation group(n=46)on this basis were treated with Celecoxib.Analgesic effect,5-HT,NE levels and adverse reactions of two groups of patients were compared.Results:After treatment,the NRS score in the observation group was lower than that in the control group,and the effective response rate in the observation group was higher than that in the control group.The 5-HT and NE levels in the observation group were lower than those in the control group(P<0.05).The incidence of constipation in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:OxyContin combined with Celecoxib in the treatment of gynecological malignancies pain has the exact effect,can reduce the adverse reactions of OxyContin alone,worthy clinical promotion.