期刊文献+

CD19-CAR-T细胞治疗急性B淋巴细胞白血病的护理 被引量:4

下载PDF
导出
摘要 目的总结CD19-CAR-T细胞治疗复发难治急性B淋巴细胞白血病(B-ALL)患者的观察护理,以期为CD19-CAR-T细胞治疗的护理提供参考。方法选取2015年5月—2017年1月收治于同济大学附属同济医院的复发性难治B-ALL患者28例,进行回顾分析。结果 28例患者均顺利完成CD19-CAR-T细胞治疗,通过1个月病情评估,完全缓解(CR)16例,无效退出试验8例,疾病发展并发感染死亡4例。结论对复发难治急性B淋巴细胞白血病患者应用CD19-CAR-T细胞治疗,采取相应的护理措施,对于难治复发B-ALL患者治疗具有积极意义。
出处 《上海护理》 2019年第2期45-47,共3页 Shanghai Nursing
  • 相关文献

参考文献3

二级参考文献40

  • 1Gkbuget N,Stanze D,Beck J,et al.Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy,prognostic factors,and performance of stem cell transplantation.Blood,2012,120(10):2032-2041.
  • 2Plosker GL,Figgitt DP.Rituximab:a review of its use in nonHodgkin's lymphoma and chronic lymphocytic leukaemia.Drugs,2003,63(8):803-43.
  • 3Morgan RA,Yang JC,Kitano M,et al.Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.Mol Ther,2010,18(4):843-851.
  • 4Jena B,Dotti G,Cooper L.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.Blood,2010,116(7):1035-1044.
  • 5Scholler J,Brady TL,Binder-scholl G,et al.Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells.Sci Transl Med,2012,4(132):132ra53.
  • 6Brentjens RJ,Latouche JB,Santos E,et al.Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.Nat Med,2003,9(3):279-286.
  • 7Brentjens RJ,Santos E,Nikhamin Y,et al.Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts.Clin Cancer Res,2007,13(18):5426-5435.
  • 8June CH,Blazar BR,Riley JL.Engineering lymphocyte subsets:tools,trials and tribulations.Nat Rev Immunol,2009,9(10):704-716.
  • 9Milone MC,Fish JD,Carpenito C,et al.Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased anti leukemic efficacy in vivo.Mol Ther,2009,17(8):1453-1464.
  • 10Porter DL,Levine BL,Kalos M,et al.Chimeric antigen receptormodified T cells in chronic lymphoid leukemia.N Engl J Med,2011,365(8):725-33.

共引文献22

同被引文献52

引证文献4

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部