摘要
血脑屏障是外周循环系统与大脑组织之间的一个动态的屏障,其对多肽类药物的通透性直接影响了药物作用于中枢神经系统的疗效。随着神经科学、遗传工程等技术的发展,大量蛋白质或多肽类药物得以应用于神经系统疾病,许多蛋白或多肽类药物均有对中枢神经系统的生物活性,而血脑屏障的存在,阻碍了这些物质进入中枢神经系统发挥疗效。本文总结概括了肽类物质的转运机制、促进多肽类药物跨血脑屏障能力的途径以及介绍了已知的能透过血脑屏障蛋白及多肽,希望为蛋白及多肽类中枢神经系统药物提供一些方向。
The blood-brain barrier(BBB)is a dynamic barrier between the peripheral circulatory system and brain tissue,whose permeability to polypeptide drugs has a direct impact on the effect of drugs on the central nervous system(CNS).With the development of neuroscience and genetic engineering technology,a large number of protein and polypeptide drugs have been applied to the treatment of nervous system diseases.Many protein and polypeptide drugs have biological activities on the CNS,but the BBB prevents these substances from entering the CNS and exerting therapeutic effects.The mechanisms of transport of peptides and ways of promoting the penetration of the BBB by polypeptide drugs are summarized in this article and proteins or peptides known to penetrate the BBB are introduced.It is hoped that this paper will provide some direction for the development of CNS drugs.
作者
解一舟
李玉珍
朱慧
李宏强
XIE Yizhou;LI Yuzhen;ZHU Hui;LI Hongqiang(Beijing Jiansheng Pharmaceutical Co.Ltd,Beijing 100039,China)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第2期128-134,共7页
Chinese Journal of Comparative Medicine
基金
北京市密云区区级科技三项费
关键词
血脑屏障
通透性
中枢神经系统
多肽
blood-brain barrier
permeability
central nervous system
peptide