颅脑未破裂动脉瘤行血管内介入疗法后发生神经并发症的相关因素研究

Related factors of neurological complications after interventional therapy for unruptured intracranial aneurysms

目的探索颅脑未破裂动脉瘤行血管内介入疗法后发生神经并发症的相关因素。方法选取128例行血管内介入疗法的颅脑未破裂动脉瘤患者为研究对象,收集患者临床资料并进行回顾性分析,探索影响颅脑未破裂动脉瘤患者发生神经并发症的因素。结果观察组患者高血压病史、吸烟、脑缺血发作史、脑梗死病史、心血管疾病、动脉瘤形态不规则或有子囊以及动脉瘤最大径>10 mm的比例明显高于对照组(X^2分别=5.27、4.53、4.96、4.90、4.18、4.65、4.87,P均<0.05)。多因素分析显示有脑梗死病史、脑缺血发作史、心血管疾病、动脉瘤最大直径>10 mm以及动脉瘤形态不规则或者有子囊是影响颅脑未破裂动脉瘤患者发生神经并发症的危险因素(OR分别=1.44、1.89、1.98、3.01、2.14,P均<0.05)。结论有脑梗死病史、脑缺血发作史、心血管疾病、动脉瘤最大直径>10 mm以及动脉瘤形态不规则或者有子囊是影响颅脑未破裂动脉瘤患者行介入疗法后发生神经并发症的危险因素。

Objective To explore the risk factors of neurological complications after interventional therapy for unruptured intracranial aneurysms.Methods Totally 128 patients with unruptured craniocerebral aneurysms were selected as the subjects,and the clinical data were collected and analyzed retrospectively.Results The proportions of hypertension,smoking,history of cerebral ischemic attack,history of cerebral infarction,cardiovascular disease,aneurysm irregular shape or ascus and the maximum diameter of aneurysm longer than 10 mm in the observation group were significantly higher than those of the control group(χ^2=5.27,4.53,4.96,4.90,4.18,4.65,4.87,P<0.05).Multivariate analysis showed that the history of cerebral infarction,history of cerebral ischemic attack,cardiovascular disease,maximum diameter of aneurysm longer than 10 mm,and aneurysm morphology irregular shape or ascus were risk factors for neurological complications in patients with unruptured aneurysms(OR=1.44,1.89,1.98,3.01,2.14,P<0.05).Conclusion The history of cerebral infarction,the history of cerebral ischemia,cardiovascular disease,the maximum diameter of the aneurysm longer than 10 mm,and the irregular shape of the aneurysm or the asiasa are the risk factors for the neurocomplications after the interventional therapy for the patients with craniocerebral unruptured aneurysms.