轻-中度慢性肾功能不全与冠状动脉病变的相关性研究

Correlation of Mild and Moderater Chronic Kidney Disease with Coronary Artery Disease

目的该研究旨在通过冠状动脉CTA来探讨轻-中度慢性肾功能不全与冠状动脉病变的相关性。方法研究纳入206例怀疑冠状动脉心脏病行冠状动脉CCTA的患者,其中正常eGFR组109例,轻度肾功能不全组66例,中度肾功能不全组31例。结果与正常eGFR组对比,轻度或中度肾功能不全组冠状动脉病变的发病率更高。运用logistic回归分析显示中度肾功能不全是任何斑块、钙化斑块、混合斑块、重度狭窄及多支血管病变的独立危险因素,而轻度肾功能不全是混合斑块发生的独立危险因素。结论轻度及中度慢性肾功能不全与冠状动脉病变的发生密切相关,肾功能损害越严重,提示冠状动脉病变的发生率越高。

Objective This present study explored the correlation of mild and moderater chronic kidney disease(CKD) with coronary artery disease(CAD). Methods We enrolled 206 subjectswho were suspected coronary artery disease(CAD) undergoing CCTA. Patients were divided into normal eGFR group(n=109), mild CKD group(n=66) and moderate CKD group(n=31). Results Compared with normal eGFR group, subjects with mild or moderater CKD had a higher prevalence of CKD(P<0.05). After adjustment for tarditional risk factors, moderate CKD was independently correlate with the prevalence of coronary plaque, CP, MP, severe coronary stenosis and multi-vessesl disease, meanwhile, mild CKD was ndependently correlate with the prevalence of the prevalence of MP. Conclusion Mild and moderater AVC were closely related with CAD. Along with the deteriorate of renal function, the morbidity of CAD will rise gradually.