MR示踪磁标记脐带间充质干细胞脑移植的实验研究

In Vivo Traceing of Umbilical Cord Mesenchymal Stem Cells Labelled by Feridex in Murine Brain

目的研究干细胞移植后活体内无创示踪方法的价值。方法菲立磁标记人脐带间充质干细胞移植到大鼠蛛网膜下腔,核磁共振成像示踪干细胞。结果移植的干细胞通过菲立磁标记后可在核磁共振成像下显示踪迹,并可从蛛网膜下腔迁移至脑实质内。结论核磁共振成像可活体无创显示菲立磁标记的干细胞的迁移,磁敏感加权成像(susceptibility-weighted imaging,SWI)示踪效果优于核磁共振T2WI平扫。

Objective To explore the value of noninvasive traceing of transplanted stem cells in vivo.Methods Feridex labelled umbilical mesenchymal stem cells were transplanted into murine subarachnoid space,and traced by MR.Results Feridex labelled stem cells can immigrate into cerebral tissue,and can be traced in vivo by MR.Conclusion MR can demonstrate the immigration of Feridex labelled stem cells into murine brain.The tracer effect of SWI was superior to T2WI.