非小细胞肺癌患者肺CT灌注成像特点及其与病理参数的关系

Characteristics of CT Perfusion Imaging and the Relationship with Pathological Parameters in Non-small Cell Lung Cancer

目的探究非小细胞肺癌(NSCLC)患者肺CT灌注成像特点及其与病理参数的关系。方法回顾性分析2015年5月-2016年5月经手术病理证实为NSCLC的48例患者肺CT灌注成像资料,分析不同病理参数与血流量(BF)、血容量(BV)、主动脉强化峰值(PEI)、平均通过时间(MTT)的关系。结果不同组织学类型NSCLC患者CT灌注成像特点比较差异均无统计学意义(P>0.05);淋巴结转移患者BF值和PEI值显著低于未发生淋巴结转移患者;随分化程度增高,BF值和PEI值逐渐上升,pTNM分期低分期患者BF值显著高于高分期患者,术后出现转移或复发患者BF值显著低于未转移或复发患者,以上差异均有统计学意义(P<0.05)。结论 CT灌注成像可通过评价血管生成情况,在一定程度上反映肿瘤恶性程度,为NSCLC患者的临床治疗及预后评估提供重要指导。

Objective To investigate the characteristics of CT perfusion imaging and the relationship with pathological parameters in patients with non-small cell lung cancer(NSCLC).Methods The lung CT perfusion imaging data of 48 patients with NSCLC confirmed by operation and pathology during the period from May 2015 to May 2016were analyzed retrospectively.The relationships between pathological parameters and CT perfusion parameters such as blood flow(BF),blood volume(BV),peak enhancement image(PEI)and mean transit time(MTT)were analyzed.Results There were no significant differences in characteristics of CT perfusion imaging between different histological types of NSCLC(P>0.05).The BF and PEI values of patients with lymph node metastasis were significantly lower than those in patients without lymph node metastasis.With the increase of differentiation degree,BF and PEI values increased gradually.The BF value of patients with low pTNM stage was significantly higher than that of patients with high stage.The BF value of patients with metastasis or recurrence was significantly lower than that of patients without(all P<0.05).Conclusion CT perfusion imaging can reflect the degree of malignancy of tumors to some extent by evaluating the status of angiogenesis,which provides important guidance for clinical treatment and prognosis evaluation of patients with NSCLC.