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Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders 被引量:1

Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders
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摘要 Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are metabolically dependent on the activity of astrocytes, a derangement of the lactate shuttle caused by a separation between the plasma membranes of neurons and astrocytes would result in metabolic impairment of the neurons themselves. In glaucoma, the triggering event has been attributed to the posterior deviation of aqueous humor towards the astrocyte-rich prelaminar tissue of the optic nerve head. The mean calcium content in the aqueous is able to interfere with calcium-dependent adherent junctions and induce anoikis of the astrocytes. As the cerebrospinal fluid has a similar base calcium concentration, a shunt of cerebrospinal fluid through the cerebral parenchyma would be able to interfere in the astrocytic architecture with dire consequences to the metabolically dependent neurons. Here the similitude between glaucoma,amyotrophic lateral sclerosis and Alzheimer's disease are discussed and the concept of the break in the fluid-brain barrier, as an event separated from the blood-brain barrier, is stressed. Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are metabolically dependent on the activity of astrocytes, a derangement of the lactate shuttle caused by a separation between the plasma membranes of neurons and astrocytes would result in metabolic impairment of the neurons themselves. In glaucoma, the triggering event has been attributed to the posterior deviation of aqueous humor towards the astrocyte-rich prelaminar tissue of the optic nerve head. The mean calcium content in the aqueous is able to interfere with calcium-dependent adherent junctions and induce anoikis of the astrocytes. As the cerebrospinal fluid has a similar base calcium concentration, a shunt of cerebrospinal fluid through the cerebral parenchyma would be able to interfere in the astrocytic architecture with dire consequences to the metabolically dependent neurons. Here the similitude between glaucoma,amyotrophic lateral sclerosis and Alzheimer's disease are discussed and the concept of the break in the fluid-brain barrier, as an event separated from the blood-brain barrier, is stressed.
机构地区 Department of Surgery
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第6期962-966,共5页 中国神经再生研究(英文版)
关键词 fluid-brain barriers blood-brain barrier CEREBROSPINAL FLUID aqueous humor calcium ion GLAUCOMA amyotrophic lateral SCLEROSIS Alzheimer’s disease fluid-brain barriers blood-brain barrier cerebrospinal fluid aqueous humor calcium ion glaucoma amyotrophic lateral sclerosis Alzheimer's disease
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  • 1Caprioli J, Coleman AL (2010) Blood flow in glaucoma discussion. Blood pressure, perfusion pressure, and glaucoma. Am J Ophthalmol 149:704-712.
  • 2Carreras FJ, Porcel D, Garzon I, A1aminos M (2009) Cell-cell adhesion in the prelaminar region of the optic nerve head: a possible target for ionic stress. Ophthalmic Res 42: 1 06-111.
  • 3Carreras FI, Porcel D, Munoz-Aviles 1 (2010a) Mapping the surface astrocytes of the optic disc: a fluid-conducting role of the astrocytic covering of the central vessels. Clin Experiment Ophthalmol 38:300-308.
  • 4Carreras FI, Porcel D, Guerra I, Carreras I (2010b) Fenestrations and preferential ?low routes in the prelaminar optic nerve through wet scanning electron microscope and perfusion of tracers. Clin Experiment OphthalrnoI38:705-717.
  • 5Carreras FI, Rica R, Delgado AV (2011a) Modeling the patterns of visual field loss in glaucoma. Optom Vis Sci 8:E63-79.
  • 6Carreras FI, Porcel D, Rodriguez-Hurtado F, Zarzuelo A, Carreras I, Galisteo M (2011b) Expression of Metabolic Coupling and Adhesion Proteins in the Porcine Optic Nerve Head: Relevance to a Flow Model of Glaucoma. Chapter 4 in The Mistery of Glaucoma. Dr. Tomas Kubena (Editor)- ln'Iech Open Access Publisher. ISBN 978-953-307-567-9.
  • 7Mozaffarieh M, Flammer I (2009) Ocular blood flow and glaucomatous optic neuropathy. Springer Verlag, Berlin Germany.
  • 8Nucci C, Osborne N, Bagetta G, Cerulli L (2008) Glaucoma: an open-window to neurodegeneration and neuroprotection. Elsevier, Burlington, MA, USA.

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