非高血压脑出血病因学研究进展

Advance in Etiology of Non-hypertensive Cerebral Hemorrhage

在非高血压性ICH病因中,脑血管结构病变如脑AVMs、海绵状血管瘤、rete MCA等可能通过病变局部血管结构及血流动力学的变化导致患者ICH风险增加;抗凝药和溶栓药物的应用可能通过改变患者血液凝结状态导致ICH;目前还发现抗抑郁药物等其他药物也有潜在导致患者ICH发生的风险,其机制尚不明确。研究还发现,一些全身性因素如血糖异常、肝功能异常,甚至儿童时期的生长暴露也可能影响患者的ICH风险。

Non-hypertensive intracerebral hemorrhage has various causes.Cerebrovascular structural abnormality such as arteriovenous malformation,cavernous hemangioma,aneurysm and venous dysplasia may increase the risk of cerebral hemorrhage by changing the local vascular structure and hemodynamics;the use of anticoagulants and thrombolytic drugs may lead to intracerebral hemorrhage by disturbing the normal blood clotting state of patients;the other drugs such as antidepressants may bring about a potential risk of intracerebral hemorrhage,while the underlying mechanism remains unclear;in addition,many studies have showed some systemic factors may be involved in intracerebral hemorrhage,such as abnormal blood sugar,liver dysfunction,and even growth exposure in childhood.This article reviewed that the advance in the etiology of non-hypertensive intracerebral hemorrhage.