长链非编码核糖核酸及其介导的竞争内源性核糖核酸与卒中发病机制研究进展

Research Progress in lncRNA and ceRNA Mediated by lncRNA in Stroke

长链非编码核糖核酸(long noncoding RNA,lncRNA)是长度大于200碱基的非编码RNA,为竞争内源性RNA(competing endogenous RNA,ceRNA)的关键组成分子,具有重要的生物学功能。近期研究表明,lncRNA及其介导的ceRNA与卒中的发病、炎症反应及血管生成密切相关,为卒中的诊治提供了新的方向。本文对lncRNA及其介导的ceRNA与卒中关系的研究进展进行综述。

Long noncoding RNA(lncRNA)represents a class of transcripts longer than 200 nucleotides and is a vital molecular component for competing endogenous RNA(ceRNA),which has significant biological function.Recent studies indicated that lncRNA and ceRNA mediated by lncRNA are closely related to the risk of stroke,inflammation and angiogenesis in stroke,which provides a new direction for the diagnosis and treatment of stroke.This article reviewed that the research progress of lncRNA and ceRNA mediated by lncRNA in stroke.