滋阴清热方治疗阴虚火旺型复发性口腔溃疡的效果

Effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration with yin deficiency and fire-excess syndrome

目的研究滋阴清热方治疗阴虚火旺型复发性口腔溃疡的效果。方法选取2017年8～12月我院纳入的44例阴虚火旺型复发性口腔溃疡患者作为研究对象,根据治疗方法的不同将其分为研究组与对照组,每组各22例。研究组患者采取滋阴清热方治疗,对照组采取常规治疗。比较两组患者的临床治疗结果。结果治疗前,两组患者的各项炎症因子[白介素-2(IL-2)、白介素-8(IL-8)及肿瘤坏死因子(TNF-α)]水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的IL-2水平高于治疗前,IL-8、TNF-α水平低于治疗前,但研究组患者的IL-2水平高于对照组,IL-8及TNF-α水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的各项免疫细胞指标(CD3^+、CD4^+、CD8^+及CD4^+/CD8^+)、血浆内皮素-1水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的CD3^+、CD4^+、CD8^+以及CD4^+/CD8^+水平均高于治疗前,血浆内皮素-1水平低于治疗前,但研究组患者的CD3^+、CD4^+、CD8^+以及CD4^+/CD8^+水平均高于对照组,血浆内皮素-1水平低于对照组,差异有统计学意义(P<0.05)。结论阴虚火旺型复发性口腔溃疡患者采取滋阴清热方治疗效果显著,可有效改善血浆内皮素-1指标水平,促进炎症消退,稳定免疫细胞水平,促进病情快速康复,为预后提供保障。

Objective To study the effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration (ROU) with yin deficiency and fire-excess syndrome. Methods A total of 44 patients of ROU with yin deficiency and fire-excess syndrome treated in our hospital from August to December 2017 were selected as subjects. According to the different treatment methods, they were divided into study group and control group, 22 cases in each group. Patients in the study group were treated with Ziyin Qingre Decoction, while those in the control group were treated with conventional therapy. The therapeutic effect was compared between the two groups. Results Before treatment, there were no statistically significant differences in the levels of inflammatory cytokines (interleukin-2 [IL-2], interleukin-8 [IL-8] and tumor necrosis factor [TNF-α]) between the two groups (P>0.05). After treatment, IL-2 levels were higher in the two groups than before treatment, and IL-8 and TNF-α levels were lower in the two groups than those before treatment, however, IL-2 levels was higher in the study group than that in the control group, and IL-8 and TNF-α levels in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). Before treatment, there were no statistically significant differences in the levels of various immune cell indicators (CD3^+, CD4^+, CD8^+ and CD4^+/CD8^+) and plasma endothelin-1 between the two groups (P>0.05). After treatment, the levels of CD3+, CD4^+, CD8^+ and CD4^+/CD8^+ in both groups were higher than those before treatment, and the levels of plasma endothelin-1 were lower than those before treatment, but the levels of CD3+, CD4^+, CD8^+ and CD4^+/CD8^+ in the study group were higher than those in the control group, and the levels of plasma endothelin-1 were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion The Ziyin Qingre Decoction can remarkably improve the plasma endothelin-1 levels, reduce the inflammatory factors, stabilize the immune cell levels, promote the fast recovery and keep the favorable prognosis.