丹红注射液治疗冠心病心绞痛的临床效果

Clinical effect of Danhong Injection in the treatment of coronary heart disease with angina pectoris

目的探讨丹红注射液治疗冠心病心绞痛的临床效果。方法选取2015年4月～2017年4月我院收治的80例冠心病心绞痛患者作为研究对象,依据治疗方法将患者分为对照组(n=40)和观察组(n=40)。对照组患者进行常规治疗,观察组患者接受常规治疗联合丹红注射液治疗。比较两组患者的治疗效果、血脂情况、C反应蛋白、心电图改善情况及不良反应发生情况。结果观察组患者的治疗总有效率为90.0%(36/40),显著高于对照组的70.0%(28/40),差异有统计学意义(P<0.05)。两组患者治疗前的总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白、C反应蛋白水平比较,差异无统计学意义(P>0.05);两组患者治疗后的总胆固醇、三酰甘油、C反应蛋白水平均显著低于治疗前,低密度脂蛋白、高密度脂蛋白水平均显著高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的总胆固醇、三酰甘油、低密度脂蛋白、C反应蛋白水平均显著低于对照组,高密度脂蛋白水平高于对照组,差异有统计学意义(P<0.05)。观察组患者的心电图总改善率为70.0%(28/40),显著高于对照组的50.0%(20/40),差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹红注射液能够有效改善冠心病心绞痛患者的治疗效果及心电图,且不会增加患者的不良反应。

Objective To investigate the clinical effect of Danhong Injection in the treatment of coronary heart disease with angina pectoris. Methods A total of 80 cases of coronary heart disease patients with angina pectoris in our hospital from April 2015 to April 2017 were selected as the objects, and the patients were divided into the control group (n=40) and the observation group (n=40) according to the treatment method. Patients in the control group underwent routine treatment, and patients in the observation group received conventional treatment combined with Danhong Injection. The therapeutic effect, blood lipids, C-reactive protein, improvement of electrocardiogram and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 90.0%(36/40), which was significantly higher than that in the control group accounting for 70.0%(28/40), and the difference was statistically significant (P<0.05). There were no significant differences in the levels of total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, and C-reactive protein between the two groups before treatment (P>0.05). The levels of total cholesterol, triglyceride, and C-reactive protein after treatment in the two groups were significantly lower than those before treatment, the levels of low-density lipoprotein and high-density lipoprotein were significantly higher than those before treatment, and the differences were statistically significant (P<0.05). The levels of total cholesterol, triglyceride, low-density lipoprotein, and C-reactive protein after treatment in the observation group were significantly lower than those in the control group, the level of high-density lipoprotein was higher than that in the control group, and the differences were statistically significant (P<0.05). The total improvement rate of electrocardiogram in the observation group was 70.0%(28/40), which was significantly higher than that in the control group accounting for 50.0%(20/40), and the difference was statistically significant (P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Danhong Injection can effectively improve the therapeutic effect and electrocardiogram of coronary heart disease patients with angina pectoris, and it does not increase the adverse reactions of patients.