唑来膦酸治疗老年骨质疏松症的效果及对骨痛缓解的影响

Effect of Zoledronic Acid in the treatment of osteoporosis in the elderly and its effect on bone pain relief

目的探讨对老年骨质疏松症患者实施唑来膦酸治疗的效果及对骨痛缓解的影响。方法选取2015年3月～2017年4月我院收治的52例老年骨质疏松症患者作为研究对象,根据治疗方式的不同分为对照组(24例)和实验组(28例),对照组给予碳酸钙D3咀嚼片+阿法骨化醇胶丸治疗,实验组给予碳酸钙D3咀嚼片+阿法骨化醇胶丸+唑来膦酸治疗。比较两组患者的疼痛评分、血钙、血膦、碱性磷酸酶(ALP)水平及不良反应总发生率。结果实验组患者治疗3、6个月后的疼痛评分低于对照组,差异均有统计学意义(P<0.05);实验组患者治疗6个月后ALP水平为(98.27±15.36)IU/L,低于对照组的(142.27±19.36)IU/L,差异有统计学意义(P<0.05);两组患者治疗6个月后的血钙、血膦水平比较,差异无统计学意义(P>0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对老年骨质疏松症患者实施唑来膦酸治疗具有较好的效果,可显著缓解骨痛,安全性较高。

Objective To explore the effect of Zoledronic Acid treatment on elderly patients with osteoporosis and its effect on bone pain relief. Methods Fifty-two elderly patients with osteoporosis admitted to our hospital from March 2015 to April 2017 were selected as the research objects, they were divided into control group (24 cases) and experimental group (28 cases) according to different treatment methods, the control group was treated with Calcium Cartonate and Vitamin D3 Chewabie Tablets and Alfacalciferol soft Capsules, while the experimental group was treated with Calcium Carttonate and Vitamin D3 Chewabie Tablets, Alfacalciferol soft Capsules and Zoledronic Acid. Pain score, serum calcium, phosphorus, alkaline phosphatase (ALP) levels and total incidence of adverse reactions were compared between the two groups. Results The pain score of the experimental group after 3 and 6 months of treatment was lower than that of the control group, the differences were statistically significant(P<0.05). After 6 months of treatment, the ALP level in the experimental group was (98.27±15.36) IU/L, which was lower than (142.27±19.36) IU/L in the control group , the difference was statistically significant (P<0.05). There were no significant differences in serum calcium and phosphorus levels between the two groups after 6 months of treatment (P>0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Zoledronic Acid has a good effect on elderly patients with osteoporosis. It can significantly alleviate bone pain and has high safety.