摘要
Ferroptosis is a novel form of regulated cell death distinguished from apoptosis,autophagy and other forms of cell death.It is characterized by the iron-dependent accumulation of reactive oxygen species to lethal levels.The inducers of cell ferroptosis react with glutathione peroxidase or lead to glutathione depletion through diverse pathways to decrease the antioxidant capacity and increase the level of reactive oxygen species.Multiple metabolic disorders and the disrupted homeostasis associated with a wide variety of ailments,including cancer,can lead to ferroptosis.The present review provides an overview of the mechanisms underlying ferroptosis,highlights the role of ferroptosis in cancer,and discusses the therapeutic potential of targeting ferroptosis.
基金
the National Natural Science Foundation of China(No.81772629,81772843,81702431,81702275,81702437,81602158 and 81602156)
the Tianjin Health and Family Planning Commission Foundation of Science and Technology(No.15KG142)
the Nature Science Foundation of Tianjin City(No.16PTSYJC00170)
The funders had no role in the study design,collection,analysis
interpretation of the data,in the writing of the report,or in the decision to submit this article for publication.
