关于光老化和环境污染及抗氧化剂的新认识

New Understanding of Photoaging and Environmental Pollution and Antioxidants

皮肤作为生理屏障,可保护机体免受物理性、化学性、机械性以及病原微生物的侵袭。紫外线照射是导致皮肤光老化的关键因素,此外环境污染物可与紫外线协同作用,对皮肤产生损害作用。紫外线A可以与环境污染物协同作用,引发皮肤癌。而空气污染物与紫外线反应产生的臭氧通过形成脂质过氧化产物,诱导皮肤表面的氧化应激,进而触发炎症反应,这种炎症反应也会导致皮肤过早老化。皮肤也受到颗粒物的影响,而芳烃受体在保护皮肤屏障功能、调节色素沉着、环境应答以及皮肤免疫中起关键作用。使用外源性抗氧化剂是预防光老化和环境损害的重要方法。

As a physiological barrier,skin can protect the body from invasion of physical,chemical,mechanical and pathogenic microorganisms.Ultraviolet irradiation is a key factor leading to skin photoaging.In addition,environmental pollutants can synergize with ultraviolet rays to cause damage to skin.Ultraviolet A together with environmental pollutants may cause skin cancer.Ozone produced by the reaction between air pollutants and ultraviolet rays induces oxidative stress on the skin surface through the formation of lipid peroxide products,and then triggers the inflammatory reaction,which also leads to premature aging of the skin.Skin is also affected by particulate matter,and aryl hydrocarbon receptors play a key role in protecting skin barrier function,regulating pigmentation,environmental response and skin immunity.The use of exogenous antioxidants is an important method to prevent photoaging and environmental damage.