早发型和晚发型银屑病的遗传学研究进展

Research Progress in Genetics of Early-Onset and Late-Onset Psoriasis

银屑病是一种常见的慢性复发性炎症性皮肤病,其病因和发病机制目前尚不清楚。根据发病年龄常将银屑病分为早发型银屑病和晚发型银屑病,其中早发型银屑病与遗传的相关性较晚发型银屑病强,且家族史通常阳性。HLA-Cw*0602、角质形成素、嗜乳脂样蛋白2、内质网氨基肽酶1、血管内皮生长因子等是影响早发型银屑病发病的基因。白细胞介素1是影响晚发型银屑病发病的基因。深入探究遗传因素在不同亚型银屑病中的作用,对明确银屑病发病机制、制定合理的治疗措施、降低复发率及提高生活质量有重要意义。

Psoriasis is a common and recurrent chronic inflammatory skin disease.However,the exact etiology and pathogenesis of psoriasis are still unclear.Psoriasis is often divided into early-onset psoriasis and late-onset psoriasis according to the age of onset.It is known that psoriatic patients with early onset are more likely to be familial and associated with various genetic polymorphisms including HLA-Cw*0602,corneodesmosin,butyrophilin-like 2,endoplasmic reticulum aminopeptidase 1,vascular endothelial growth factor,etc.In addition,interleukin-1 gene is associated with late-onset psoriasis.A deep dive into the role of genetic factors in different subtypes of psoriasis is important for clarifying the pathogenesis of psoriasis,developing rational treatments,reducing the incidence and improving the quality of life.