利用种子细胞及新型生物材料进行尿道狭窄修复的研究进展

Research Progress in the Repair of Urethral Stricture with Seed Cells and New Biomaterials

组织工程学的发展为尿道狭窄的修复提供了新方法。组织工程修复的种子细胞具有自我更新及多向分化的潜能。目前脂肪干细胞、骨髓干细胞以及尿源性干细胞等已经开始尝试应用于尿道组织工程的修复。应用于尿道组织工程修复的生物材料主要包括两大类,一类是天然衍生材料,另一类是人工合成材料,两种材料各具优缺点。新型支架是含有人工合成及天然生物成分的混合支架材料,兼具天然衍生材料和人工合成材料的优点,在促进愈合、减少瘢痕,促进局部血运等方面具有优越性。

The development of tissue engineering provides a new method for the repair of urethral stricture.Seed cells repaired by stem cells tissue engineering have the potential of self-renewal and multi-directional differentiation.Adipose stem cells,bone marrow stem cells and urine-derived stem cells have been reported to be used in urethral tissue engineering.There are two main types of biomaterials for urethral tissue engineering repair:one is natural derivatives,the other is synthetic materials,each with own advantages and disadvantages.The new scaffold contains a mixture of artificial and natural biological components,therefore has the advantages of both materials,which are promoting healing,reducing scars and promoting local blood supply.