糖尿病心肌病发病机制的研究进展

Research Progress in Pathogenesis of Diabetic Cardiomyopathy

糖尿病心肌病(DCM)是糖尿病的重要并发症之一,是独立于冠状动脉疾病和高血压的一个常见的心血管合并症。该病在心肌细胞代谢紊乱及微血管病变的基础上引发心肌细胞肥大,心肌成纤维细胞增殖和胶原沉积,造成心室壁僵硬、心功能损伤,最终导致心力衰竭。迄今有关DCM的确切发病机制尚不完全明确。研究认为DCM是糖脂代谢紊乱、胰岛素分泌异常等综合作用的结果。细胞自噬异常,多因素共同作用引起亚细胞组分异常、不适应性免疫应答等参与DCM的发生、发展。

Diabetic cardiomyopathy(DCM)is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension.This disease causes hypertrophy of cardiac cells,proliferation of cardiac fibroblasts and collagen deposition on the basis of metabolic disorders of cardiac cells and microvascular diseases,resulting in stiff ventricular wall and cardiac function injury,and eventually leads to heart failure.To date,the exact pathogenesis of DCM is not completely clear.It is believed that DCM is the result of the combined action of sugar,fat metabolism disorder and insulin secretion abnormality.Abnormal cell autophagy has been discovered,and the co-action of multiple factors that cause abnormal subcellular components and inadaptive immune responses are also involved in the occurrence and development of DCM.