黄连素治疗非甾体抗炎药相关性溃疡合并幽门螺杆菌感染疗效研究

Clinical Effect of Berberine in the Treatment of Non-Steroidal Anti-Inflammatory Drugs Associated Peptic Ulcer Complicated with Helicobacter Pylori Infection

目的探讨黄连素治疗消化道非甾体抗炎药(NSAIDs)相关性溃疡合并幽门螺杆菌的疗效。方法选取医院2015年12月至2017年2月收治的幽门螺杆菌(HP)阳性的消化性溃疡患者56例,均于治疗前已至少服用NSAIDs 4周且治疗过程中不停用,按随机数字表法分为对照组(30例)和观察组(26例)。对照组患者给予雷贝拉唑钠肠溶片10 mg、枸橼酸铋钾颗粒220 mg、阿莫西林胶囊1 000 mg及呋喃唑酮片100 mg,均每日2次治疗;观察组患者在对照组基础上加用黄连素片(每次300 mg,每日3次)。结果两组患者症状缓解率(86. 67%比96. 15%)及不良反应发生率(26. 67%比11. 54%)均相当(P> 0. 05),但观察组HP根除率及消化性溃疡治疗总有效率均为100. 00%,显著高于对照组的83. 33%和80. 00%(P <0. 05)。结论黄连素联合铋剂四联疗法可显著提高HP根除率,促进消化性溃疡的愈合,效果优于单纯铋剂四联疗法。

Objective To investigate the clinical effect of berberine in the treatment of non-steroidal anti-inflammatory drugs(NSAIDs)associated peptic ulcer and Helicobacter pylori(HP)infection.Methods Totally 56 HP-positive patients with peptic ulcer admitted to our hospital from December 2015 to February 2017 were selected,all the patients were treated with NSAIDs for at least 4 weeks,and the NSAIDs were not stopped during the treatment.All the patients were divided into the control group(n=30)and the observation group(n=26)by the random number table method.The patients in the control group were given 10 mg Rabeprazole Sodium Enteric-Coated Tablets,220 mg Bismuth Potassium Citrate Granules,1 000 mg Amoxicillin Capsules and 100 mg Furazolidone Tablets,all drugs were administered twice a day,on this basis,the patients in the observation group were given berberine(300 mg per time,three times a day).Results The remission rate of symptoms(86.67%vs.96.15%)and the incidence rate of adverse reactions(26.67%vs.11.54%)were similar between the two groups(P >0.05),but the eradication rate of HP and the total effective rate for the treatment of peptic ulcer in the observation group were 100.00%,which were significantly higher than 83.33%and 80.00%in the control group(P<0.05).Conclusion Berberine combined with bismuth quadri-combination therapy can significantly improve the eradication rate of HP and promote the healing of peptic ulcer,its effect is superior to the effect of bismuth quadri-combination therapy alone.