FoxM1调节网络——抗癌新靶点

FoxM1-regulatory network:Anticancer new target

哺乳动物叉头框蛋白M1(forkhead box proteinM1,FoxM1)是叉头框转录因子家族成员之一,它参与正常细胞的增殖。然而研究表明,FoxM1在多种癌症中均呈现过表达的状态,并且与Hanahan和Weinberg所描述的癌症的主要特征有关。据推测,Fox M1的致癌潜力取决于其反式激活的靶基因的能力。此外,Fox M1也可通过与其他蛋白如β-catenin或母亲DPP同源物3 (mothers against decapentaplegic homolog 3,SMAD3)相互作用分别诱导Wnt和转化生长因子-β(transforming growth factor-β,TGF-β)信号通路发挥致癌作用。在本文中我们将阐明FoxM1的蛋白质-蛋白质相互作用是癌症发展的关键,这可能成为抗癌药物的新目标。

Forkhead box protein M1 (FoxM1) is a transcription factor of the Forkhead family involved in the cell proliferation.However,studies have shown that FoxM1 is overexpressed in a variety of human cancers and associated with the major hallmarks of cancer described by Hanahan and Weinberg.It has been postulated that the oncogenic potential of FoxM1 depends on its capacity to transactivate target genes.In addition,FoxM1 can also play an oncogenic role by inducing Wnt and transforming growth factor-β(TGF-β) signaling pathways,respectively,through interacting with other proteins such as β-catenin or mothers against decapentaplegic homolog 3 (SMAD3).In this review,we will discuss the protein-protein interactions of FoxM1 that are critical for cancer development and may represent novel targets for anticancer drugs.