原发于淋巴结内、外弥漫大B细胞淋巴瘤预后影响因素分析

Prognostic factors of diffuse large B-cell lymphoma of nodal and extranodal primary origin

目的分析原发于结内、外弥漫大B细胞淋巴瘤(DLBCL)预后影响因素。方法 DLBCL患者137例,其中结内DLBCL 70例、结外DLBCL 67例,采用单因素分析法和Cox模型多因素预后分析法分析结内、外DLBCL患者预后影响因素。结果单因素分析显示,结内DLBCL的分期、B组症状、贫血、淋巴细胞绝对数、白蛋白、LDH、ECOG评分、IPI评分、病理分型、治疗方案是其预后影响因素,结外者的贫血、LDH、ECOG评分、治疗方案是其预后影响因素;多因素分析显示,结内DLBCL的治疗方案、B组症状是其预后独立危险因素,结外DLBCL的ECOG评分、LDH是其预后独立危险因素。结论治疗方案与B组症状是结内DLBCL患者的独立危险因素,ECOG与LDH是结外DLBCL患者的独立危险因素。

Objective To analyze the prognostic factors of diffuse large B-cell lymphoma(DLBCL)of nodal and extranodal primary origin.Methods There were 137 patients with DLBCL,including 70 patients with nodal DLBCL(N-DLBCL)and 67 patients with extranodal DLBCL(EN-DLBCL).The clinical characteristics of the two groups were compared.Kaplan-Meier survival analysis and Cox model multivariate prognostic analysis were used to analyze the prognostic factors of patients with N-DLBCLand EN-DLBCL.Results Univariate analysis indicated that Ann Arbor staging,B-symptoms,anemia,peripheral blood absolute lymphocyte count,albumin,lactate dehydrogenase(LDH),ECOG score,IPI score,pathological type,and therapeutic regimen were prognostic factors for N-DLBCL;the anemia,LDH,ECOG score,and therapeutic regimen were prognostic factors for EN-DLBCL.Multivariate analysis showed that the therapeutic regimen and B-symptoms were independent prognostic factors for N-DLBCL,while ECOG score and LDH were independent prognostic factors for EN-DLBCL.Conclusion The therapeutic regimen and B-symptoms are independent prognostic factors of N-DLBCL,while ECOG score and LDH are independent prognostic factors of EN-DLBCL.