生物钟与缺氧诱导因子在肿瘤领域的相关性

Correlation between circadian rhythms and hypoxia inducible factor in the tumor area

生物钟是机体为适应周围环境,经过长期进化而来的内在适应性反应,它受外界环境(辐射、药物等)影响引起DNA损伤而使节律重新设置。肿瘤的发生、发展可改变机体微环境,近期越来越多研究表明肿瘤疾病进展与机体生物钟紊乱密切相关。本文通过对生物钟和缺氧诱导因子(hypoxia-induciblefactor,HIF)的结构、调控及表达角度分析,对缺氧及生物钟相关性进行综述性介绍,以期凭靶向调节生物钟来改善机体肿瘤疾病进展的研究提供参考,同时希望能促进时间生物学领域与更多其他领域形成交叉研究。

The circadian clocks are internal adaptive responses which are evolved to adapt to the surrounding environment for the organisms. They can be affected by the external environments (such as radiation, drugs, etc.) and cause DNA damages and reset the rhythms. The occurrence and development of tumors can change the microenvironment of the body. Recently, more and more studies have shown that the progression of tumor diseases is closely related to the disorder of circadian rhythms. In this review, we analyze the structures, regulations and expressions of circadian clocks and hypoxia inducible factors to summarize the correlation between them. Besides, we hope it can offer basic knowledge for further researches, a reference for experimental designs aiming to adjust the progressions of neoplastic diseases by modulating the circadian rhythms, and provide a foundation to build interdisciplinary research networks.