马来酸依那普利叶酸片治疗H型高血压的效果

Effect of Enalapril Maleate-folic Acid Tablets on H-type Hypertension

目的探讨马来酸依那普利叶酸片降压、降低同型半胱氨酸水平的临床效果。方法 H型高血压患者84例,采用随机数字表法分为两组,对照组42例采用马来酸依那普利片治疗,观察组42例采用马来酸依那普利叶酸片治疗,于治疗前后行血压、同型半胱氨酸检测。比较两组的治疗效果及不良反应。结果两组治疗后舒张压、收缩压、同型半胱氨酸较治疗前降低(P <0.05)。观察组治疗后舒张压、收缩压、同型半胱氨酸低于对照组(P <0.05)。观察组总有效率高于对照组(P<0.05)。两组不良反应(头痛、眩晕、便秘、干咳)比较,差异无统计学意义(P> 0.05)。结论马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效显著。

Objective To investigate the clinical effect of enalapril maleatefolic acid tablets in reducing blood pressure and homocysteine.Methods 84 patients with type H hypertension were divided into two groups by random number table method.42 patients treated with enalapril maleate tablets were selected as control group.42 patients treated with enalapril maleate-folic acid tablets were selected as observation group.Blood pressure and the level of homocysteine was detected before and after treatment.Treatment effect and adverse reactions were compared between two groups.Results Diastolic blood pressure,systolic blood pressure,the level of homocysteine decreased in two groups after treatment(P<0.05).Diastolic blood pressure,systolic blood pressure,the level of homocysteine in observation group were lower than those in control group after treatment(P<0.05).Total effective rate in observation group was higher than that in control group(P<0.05).There were no significant differences in adverse reactions(headache,vertigo,constipation,dry cough)between two groups(P >0.05).Conclusion Enalapril maleate-folic acid tablets has significant effect in reducing blood pressure and homocysteine.