多索茶碱的研究进展

Research progress of doxofylline

多索茶碱是一种甲基黄嘌呤衍生物,其作为一种新的支气管扩张药,在治疗慢性阻塞性肺疾病和哮喘方面具有良好的药理学作用和临床效果。与传统的茶碱相比,多索茶碱具有不拮抗钙通道受体,也不影响钙内流,且对腺苷A_1和A_2受体亲和力很弱等特点,因而其不影响心率和节律、睡眠节律、中枢神经系统(CNS)的功能以及胃分泌,且具有良好的安全性和耐受性。本文综述了多索茶碱的研究进展,以期为广大医务工作者提供参考。

Doxofylline is a methylxanthine derivative that acts as a new bronchodilator with good pharmacological effects and clinical efficacy in the treatment of chronic obstructive pulmonary disease and asthma.Compared with traditional theophylline,doxofylline has the characteristics of not antagonizing calcium channel receptors,nor affecting calcium influx,and has a weak affinity for adenosine A1 and A2 receptors,so it does not affect heart rate and rhythm,sleep rhythm,central nervous system(CNS)function and gastric secretion,and has good safety and tolerance.This article reviews the research progress of doxofylline in order to provide reference for the majority of medical workers.