摘要
微小RNA(microRNA, miRNA)是一种重要的转录后基因表达调节因子,其表达谱的变化与许多人类病理学有关。miRNA与人类免疫缺陷病毒(human immunodeficiency virus,HIV)之间的相互关系已成为全球研究的热点之一。本文主要从miRNA对HIV-1病毒的转录复制、潜伏感染的影响,miRNA在HIV-1相关疾病中的研究,及其对人类获得性免疫缺陷综合征(acquiredimmunodeficiency syndrome,AIDS)的治疗前景进行综述。
MicroRNA(miRNA)is an important post-transcriptional gene expression regulator,and its expression profile changes are related to many human pathology.The correlation between miRNA and human immunodeficiency virus 1(HIV-1)has become one of the hot spots in global research.In this paper,the effects of miRNA on the transcription replication and latent infection of HIV-1 virus,the study of miRNA in HIV-1 related diseases and the therapeutic prospects of AIDS are reviewed.
作者
闫新丽
王玉明
李晓非
张润武
王红英
Yan Xinli;Wang Yuming;Li Xiaofei;Zhang Runwu;Wang Hongying(Department of Laboratory Medicine,The Third People′s Hospital of Kunming City,Kunming 650041,China;The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《中华临床实验室管理电子杂志》
2019年第1期17-21,共5页
Chinese Journal of Clinical Laboratory Management(Electronic Edition）
