免疫球蛋白治疗轮状病毒性肠炎患儿炎性反应的临床效果

Clinical effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis

目的探讨免疫球蛋白治疗轮状病毒性肠炎患儿炎性反应的临床效果。方法选取2016年10月1日～2018年2月1日我院收治的64例轮状病毒性肠炎患儿作为研究对象,按照随机抽样方法将其分为对照组组(32例)与观察组(32例)。对照组患儿采用常规对症治疗+安慰剂,观察组患儿在常规对症治疗的基础上静脉滴注免疫球蛋白。收集两组患儿的新鲜粪便作为标本进行检验,比较两组患儿的治疗总有效率、治疗前后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平变化情况及分泌性免疫球蛋白A(SIgA)水平变化。结果观察组患儿的治疗总有效率为93.75%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组患儿治疗前的TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);两组患儿治疗后的TNF-α、IL-6水平均显著低于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的TNF-α、IL-6水平均显著低于对照组,差异有统计学意义(P<0.05)。两组患儿治疗前的SIgA水平比较,差异无统计学意义(P>0.05);两组患儿治疗后第1、2、3、4、5天的SIgA水平均高于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后第1、2、3、4、5天的SIgA水平均显著高于对照组,差异有统计学意义(P<0.05)。结论免疫球蛋白治疗轮状病毒性小儿肠炎炎性反应的效果显著。

Objective To explore the effect of Immunoglobulin in the treatment of inflammatory reaction in children with rotavirus enteritis.Methods Sixty four children with rotavirus enteritis admitted to our hospital from October 1,2016 to February 1,2018 were selected as research subjects.They were divided into control group(32 cases)and observation group(32 cases)according to the random sampling method.The control group received conventional symptomatic treatment and placebo,and the observation group received intravenous Immunoglobulin on the basis of the conventional symptomatic treatment.The fresh feces of the two groups were collected as specimens.The total effective rate of treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and secretory immunoglobulin A(SIgA)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75%,which was higher than that in the control group(75.00%),and the difference was statistically significant(P<0.05).There were no significant differences in the levels of TNF-αand IL-6 between the two groups before treatment(P >0.05).The levels of TNF-αand IL-6 after treatment in the two groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of TNF-αand IL-6 after treatment in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the level of SIgA between the two groups before treatment(P >0.05).The levels of SIgA on the 1st,2nd,3rd,4th,and 5th days after treatment in the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).The levels of SIgA on the 1st,2nd,3rd,4th,and 5th days after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of Immunoglobulin is significant in the treatment of the inflammatory reaction in children with rotavirus enteritis.