阿托伐他汀钙联合氯吡格雷治疗老年短暂性脑缺血发作的近远期效果

Short-term and long-term effects of atorvastatin calcium combined with clopidogrel in the treatment of elderly transient ischemic attack

目的评价阿托伐他汀钙联合氯吡格雷治疗老年短暂性脑缺血发作(TIA)的近远期效果。方法将2014年5月至2016年7月收治入院的96例老年TIA患者按入院治疗的时间顺序分为观察组和对照组,各48例。对照组给予氯吡格雷治疗,观察组给予阿托伐他汀钙和氯吡格雷治疗。比较两组患者的近远期治疗效果、生化指标水平变化及不良反应发生情况。结果观察组患者的治疗总有效率为95.83%,高于对照组的83.33%,差异具有统计学意义(P<0.05)。治疗后,两组患者TG、TC、LDL-C及CysC水平均降低,HDL-C水平均升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。随访1年期间,观察组TIA和脑梗死总发生率为4.17%,明显低于对照组的18.75%,差异具有统计学意义(P<0.05)。结论氯吡格雷联合阿托伐他汀钙治疗老年TIA,可促进患者血脂水平的降低和凝血功能的改善,提高患者近远期临床疗效,安全性高,具有进一步推广价值。

Objective To evaluate the short-term and long-term effects of atorvastatin calcium combined with clopidogrel in the treatment of elderly transient ischemic attack(TIA).Methods Ninety-six elderly TIA patients admitted from May 2014 to July 2016 were divided into observation group and control group according to the time sequence of admission treatment,with 48 cases in each group.The control group was treated with clopidogrel,while the observation group was treated with atorvastatin calcium and clopidogrel.The short-term and long-term therapeutic effects,changes of biochemical indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.83%,which was higher than 83.33%in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of TG,TC,LDL-C and CysC in both groups decreased,while the levels of HDL-C increased,and those of the observation group were better than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).During one year follow-up,the total incidence of TIA and cerebral infarction in the observation group was 4.17%,which was significantly lower than 18.75%in the control group(P<0.05).Conclusion Clopidogrel combined with atorvastatin calcium in the treatment of elderly TIA can promote the reduction of blood lipid levels and the improvement of blood coagulation function,improve the short-term and long-term clinical effects of patients,with high safety.It has further promotion value.