磁共振T1WI健康成人脑部皮层下灰质核团纹理特征的可重复性及可信度分析

Repeatability and Reliability of MRI T1WI Texture Features of Cerebral Subcortical Gray Matter Nuclei in Healthy Adults

目的探讨正常成人脑部皮层下灰质核团的磁共振T1WI纹理特征测量的可重复性及可信度。资料与方法对16名成年健康志愿者行脑部磁共振T1WI扫描,并采用灰度共生矩阵法对脑部皮层下灰质核团(尾状核、壳核、丘脑)行纹理特征分析,纹理特征参数值包括能量、对比度、自相关、逆差矩、熵。采用组内相关系数(ICC)及Bland-Altman法分析观察者内的可重复性及观察者间的可信度。结果观察者内皮层下灰质结构尾状核头、壳核及丘脑的纹理特征参数值ICC分别为0.970～0.990、0.815～0.996及0.677～0.996,其中丘脑自相关参数ICC为0.677,可重复性等级为良,其余皮层下核团纹理参数ICC均高于0.74,可重复性等级为优。观察者间皮层下灰质结构尾状核头、壳核及丘脑的纹理特征参数值ICC分别为0.960～0.982、0.833～0.994及0.829～0.989,均高于0.74,可信度等级为优。Bland-Altman法分析提示观察者内及观察者间皮层下灰质核团纹理参数差值绝大部分位于95%一致性界限内。结论 T1WI图像可以可靠地评估正常成人脑部皮层下灰质核团纹理特征(能量、对比度、自相关、逆差矩、熵)。

Purpose To investigate the repeatability and reliability of MRI T1WI texture features measurement of cerebral subcortical gray matter nuclei in normal adults. Materials and Methods Sixteen healthy adult volunteers were performed with MRI T1WI scanning and gray-level co-occurrence matrix was taken to analyze texture features of cerebral subcortical gray matter nuclei including caudate nucleus, putamen and thalamus. Texture parameter included energy, contrast, correlation, inverse difference moment (IDM) and entropy. Intraclass correlation coefficient (ICC) and Bland-Altman method were used to evaluate the intra-observer repeatability and inter-observer reliability. Results Texture parameter ICC value of observer subcortical gray matter caput nuclei caudati, putamen and thalamus were 0.970-0.990, 0.815-0.996 and 0.677-0.996, respectively. Among, thalamus ICC was 0.677 and repeatability was classified to be good. Texture parameter ICC of remaining subcortical nuclei were all higher than 0.74 and repeatability was classified to be excellent. Texture parameter ICC value of observer subcortical gray matter caput nuclei caudati, putamen and thalamus were 0.960-0.982, 0.833-0.994 and 0.829-0.989, respectively, being all higher than 0.74, reliability was classified to be excellent. Bland-Altman analysis indicated that texture difference value of intra-observer and observer subcortical gray matter nuclei was mostly within 95%. Conclusion T1WI images could reliably be used to assess texture feature (energy, contrast, correlation, IDM and entropy) of cerebral subcortical gray matter nuclei in health adults.