膝关节腔内注射医用臭氧治疗膝骨性关节炎的临床研究

A clinical study of intra-articular injection of medical ozone for treatment of knee osteoarthritis

目的探究膝关节腔内注射医用臭氧治疗膝骨性关节炎的临床效果。方法选择我院2016年1月—2018年1月收治的72例膝骨性关节炎患者作为本次研究的对象,对其资料进行回顾性分析。将患者分为观察组与对照组,每组36例,对照组治疗方案采用关节腔内注射玻璃酸钠,观察组治疗方案采用关节腔内注射医用臭氧。分别在治疗后的第1个月、第2个月和第3个月,对两组患者的膝关节视觉模拟疼痛评分(VAS)与疗效进行对比,判断治疗效果。结果观察组总有效率为94.44%,对照组为75.00%,两组总有效率比较差异有统计学意义(P<0.05)。治疗前两组VAS评分基本一致,在治疗后1个月、治疗后2个月与治疗后3个月的VAS评分对比上,观察组均显著低于对照组,差异具有统计学意义(P<0.001)。观察组不良反应发生率(8.33%)低于对照组(27.86%),差异有统计学意义(P<0.05)。结论相比其他膝骨性关节炎治疗方案,医用臭氧膝关节腔内注射的方式疗效更为显著,在临床症状的缓解与患者膝关节活动能力的恢复方面取得了良好的效果。对于一些不适应传统药物治疗或糖皮质激素治疗的患者来说其可以作为一种合理的代替方案,臭氧改善患者关节的活动受限程度,解除患者的关节疼痛,在不良反应方面也具有良好的控制作用,今后可以作为相关疾病的优先治疗方案。

Objective To investigate the clinical effect of intra-articular injection of medical ozone in the treatment of knee osteoarthritis.Methods Seventy-two patients with knee osteoarthritis cared at our hospital from January 2016 to January 2018 were selected as this study subjects,and their data were analyzed retrospectively.The patients were divided into an observation group and a control group,and each group consisted of 36 cases.The treatment plan for the control group patients was intra-articular injection of sodium hyaluronate.The treatment plan for the observation group patients was injection of medical ozone,and the medical ozone was injected into the articular cavity.In the first,the second and the third month respectively after the treatment,the data of the knee joint visual analogue pain scale(VAS)and the treatment efficacy were compared between the two groups for assessing the therapeutic effect.Results In terms of treatment efficacy,the total effective rate of the observation group was 94.44%,and that of the control group was 75.00%,and there was statically significant difference in total effective rate between the two groups(P<0.05).The pre-treatment VAS score was almost the same between the two groups,and in comparison of the first-,the second-and the third-month VAS scores between the two groups showed that the observation group had significantly lower VAS scores than the control group,and the difference between the two groups was statistically significant(P<0.001).The observation group had lower incidence of adverse reaction(8.33%)than the control group(27.78%),the difference was statistically significant(P<0.05).Conclusion Compared with other treatments of knee osteoarthritis,the efficacy of medical ozone intra-articular injection is more significant.It has achieved good results in the relief of clinical symptoms and the recovery of the knee joint mobility.It can be a reasonable alternative for some patients who do not adapt to conventional drug therapy or glucocorticoid therapy.Ozone can improve the degree of motion limitation of the joints in patients and relieve joint pain in patients.It also has a good control effect on adverse reactions and can be used as a priority treatment scheme for related diseases in the future.