炎症因子及氧化应激在GERD食管黏膜炎症损伤发生中的作用

Role of inflammatory cytokine and oxidative stress in the development of gastroesophageal reflux disease and esophagul mucosa injury

我国胃食管反流病(GERD)发病率一直呈上升趋势。GERD病因较多,发病的机制复杂,发病机制尚未清楚。抑酸治疗是治理GERD的最佳途径,质子泵抑制剂被用于GERD的常规治疗,但仍有一部分的患者对其疗效欠佳。近年来,炎症因子(ICs)和氧化应激(OS)在食管黏膜损伤中的作用逐渐受到重视。ICs及OS为靶向的新型药物治疗,对抑酸药物疗效欠佳的GERD患者带来希望,也为其诊断和治疗开辟新的途径,本文对以上方面研究现状作一综述。

Now a days the morbidity of gastroesophageal reflux disease (GERD) has been greatly increased in China. GERD has many etiologies, and the pathogenesis are complex, yet the mechanisms of GERD has not been fully understood. Acid suppression treatment believed to be the best way of controlling the GERD, and proton pump inhibitors (PPIs) is used for routine treatment of GERD, still there were patients showed poor curative effects. In recent years, many researchers began to pay attention to the the roles of inflammatory cytokines (ICs) and oxidative stress (OS) in the development of GERD and esophagul mucosa injury. ICs and OS may the potential targets for new drug development, which brings some hope to GERD patients with poor curative effect of acid suppressor use, and may also open new ways for diagnosis and treatment of GERD.