静脉注射免疫球蛋白与血浆置换治疗重症肌无力的研究

Treatment of myasthenia gravis with intravenous immunoglobulin and plasmapheresis

目的探究静脉注射免疫球蛋白与血浆置换治疗重症肌无力的效果。方法将2016年6月至2017年6月在本院接受治疗的60例重症肌无力患者作为研究对象,按照随机数字表法分组,对照组30例,给予血浆置换治疗;观察组30例,给予免疫球蛋白静脉注射治疗,对两组患者治疗前后的免疫功能指标以及临床治疗效果进行综合评价。结果观察组患者治疗后的IgG、IgM以及IgA免疫功能指标均显著优于对照组,差异有统计学意义(P<0.05);观察组治疗后有28例患者显示有效,占93.3%,显著高于对照组的70.0%,两组差异有统计学意义(P<0.05)。结论静脉注射免疫球蛋白治疗重症肌无力,能够促进患者免疫功能指标的改善,疗效优于血浆置换治疗,效果显著,值得推广应用。

Objective To explore the effect of intravenous immunoglobulin and plasma exchange in the treatment of myasthenia gravis. Methods 60 patients with myasthenia gravis which were treated in our hospital in June 2016 to June 2017 were divided into groups with random digital table, 30 cases in control group and plasma exchange therapy;30 cases in the observation group were treated with immunoglobulin intravenous injection, and the immune function indexes and clinical treatment before and after treatment of the two groups were treated. The therapeutic effect was evaluated synthetically. Results The immune function indexes of IgG, IgM and IgA after treatment in the observation group were significantly better than those of the control group (P<0.05). There were 28 cases in the observation group, which were effective, accounting for 93.3%, significantly higher than that of the control group, and the two groups were significantly different (P<0.05), statistically significant. Conclusion Intravenous immunoglobulin in the treatment of myasthenia gravis, can promote the improvement of the immune function index of the patients, the effect is better than the plasma exchange treatment, the effect is significant, it is worthy of popularization and application.