宫腔镜术前米索前列醇三种给药方式的临床观察

Clinical Observation of Three Ways of Misoprostol before Hysteroscopy

目的:探讨宫腔镜术前米索前列醇采用舌下含服、阴道以及直肠三种给药方式的对宫颈软化的效果。方法:选择2015年1月～2017年12月我院收治的行宫腔镜手术治疗的患者180例,按照随机数字表法分为A组(舌下含服给药组)、B组(阴道给药组)和C组(直肠给药组),每组60例,观察比较三组患者的宫颈软化程度、术中疼痛程度以及不良反应发生情况。结果:A组、B组、C组患者的宫颈软化率分别为91.67%,93.33%、96.67%,三组间比较,差异无统计学意义(P>0.05)。三组患者的疼痛程度分级比较,差异无统计学意义(P>0.05)。B组、C组患者的不良反应发生率分别为11.67%、15.00%,均明显低于A组的31.67%,差异具有统计学意义(P<0.05)。结论:在行宫腔镜治疗前采用米索前列醇阴道、直肠给药的方式,可以取得良好的宫颈软化效果,患者的疼痛程度较低,不良反应发生率较低,值得在临床上大力的推广。

Objective:To investigate the effect of misoprostol on cervical softening by using three sublingual drugs, vagina and rectum. Method:180 patients with hysteroscopic surgery treated in our hospital in January 2015~December 2017 were divided into A group (sublingual administration group), B group (vaginal administration group) and C group (rectal administration group) according to the random digital table method. The degree of cervical softening, the degree of pain in the three groups, and the bad degree of pain in the three groups were observed and compared. The occurrence of the reaction. Results: the cervical softening rates of group A, group B and group C were 91.67%,93.33% and 96.67%, respectively. There was no significant difference between the three groups ( P >0.05). There was no significant difference in pain grading between the three groups ( P >0.05). The incidence of adverse reactions in group B and group C was 11.67% and 15% respectively, which were significantly lower than those in group A( 31.67%), and the difference was statistically significant ( P <0.05). Conclusion: Before and after the treatment of hysteroscopy, the use of misoprostol vaginal and rectal administration can achieve good cervical softening effect. The pain degree of the patients is low and the incidence of adverse reactions is low. It is worth popularizing in clinical.