Ⅲ型干扰素抵抗寨卡病毒感染导致不良妊娠的机制

Mechanism of type Ⅲ interferon resistance to adverse pregnancy induced by Zika virus infection

寨卡病毒是一种蚊媒黄病毒,妊娠早期妇女感染寨卡病毒可引起新生儿小头畸形、胎儿宫内发育迟缓及胎儿自发性流产等不良妊娠。人胎盘原代滋养细胞分泌的Ⅲ型干扰素及Ⅲ型干扰素诱导产生的干扰素刺激基因可在细胞中建立抗病毒状态,保护胎儿免受寨卡病毒的感染。Ⅲ型干扰素对寨卡病毒导致的不良妊娠保护作用具有阶段特异性,对妊娠早期没有保护作用。本文就寨卡病毒导致不良妊娠和Ⅲ型干扰素抵抗寨卡病毒感染等方面的机制研究进行综述,为深入了解寨卡病毒致病机制和免疫预防提供参考。

Zika virus(ZIKV)is a mosquito-borne flavivirus which can cause neonatal microcephaly,intrauterine growth retardation and fetal spontaneous abortion.Interferon λ(IFN-λ)released from placenta primary human trophoblast cells and interferon-stimulated genes(ISGs)induced by IFN-λcan establish antiviral status in cells and protect fetuses from Zika virus infection.Besides,the protection of IFN-λis gestational stage-dependent,and it does not work during early pregnancy.In this paper,the study on mechanism of IFN-λresistance against Zika virus are reviewed in order to provide references for further understanding of the pathogenic mechanism and immune prevention of Zika virus.