Eph/ephrin信号通路与神经干细胞的增殖和分化

Eph/ephrin signaling pathway and neural stem cell proliferation and differentiation

背景:研究表明,移植入宿主体内的神经干细胞可分化为神经元或神经胶质细胞。Eph/Ephrin信号通路与神经干细胞的增殖分化密切相关。通过调节Eph/Ephrin信号通路可控制神经干细胞的定向增殖分化。目的:对神经干细胞增殖、分化与Eph/Ephrin信号通路的关系进行综述。方法:应用计算机检索2000年1月至2018年11月Medline数据库、Ovid数据库、CNKI数据库、万方数据库,中文检索词为"Eph/ephrin信号通路,神经干细胞,分化,增殖",英文检索词为"Eph/ephrin signalingpathway,neural stem cells,differentiation,proliferation"。纳入与神经干细胞增殖、分化及Eph/Ephrin信号系统相关的文献,排除重复性研究,保留51篇文献进行综述。结果与结论:神经干细胞是一类具有自我更新和多向分化潜能的细胞,能分化形成中枢神经系统几乎所有类型的细胞。Eph/Ephrin信号通路在神经干细胞的增殖分化中起重要作用。文章从神经干细胞、Eph/Ephrin信号通路、Eph/Ephrin信号通路与神经干细胞的增殖分化等方面分别进行了叙述。然而,Eph/Ephrin信号通路控制神经干细胞分化的具体机制还不是很清楚。

BACKGROUND: Studies have shown that neural stem cells transplanted into a host can differentiate into neurons or glial cells. Eph/Ephrin signaling pathway is closely related to the proliferation and differentiation of neural stem cells. Directed proliferation and differentiation of neural stem cells can be controlled by modulating the Eph/Ephrin signaling pathway.OBJECTIVE: To review the neural stem cell proliferation and differentiation and its relationship with Eph/Ephrin signaling pathway.METHODS: A computer search of Medline, Ovid, CNKI, EBSCO databases(2000-01/2018-11) was performed, and the search terms were"Eph/ephrin signaling pathway, neural stem cells, differentiation, proliferation" in English and Chinese, respectively. The literatures related to neural stem cell proliferation and differentiation and Eph/Ephrin signaling system were included, and repetitive studies were excluded. Finally 51 literatures were retained for review.RESULTS AND CONCLUSION: Neural stem cells are a class of cells with self-renewal and multi-directional differentiation potential that can differentiate into almost all types of cells in the central nervous system. The Eph/Ephrin signaling pathway plays a vital role in the proliferation and differentiation of neural stem cells. This article reviews the neural stem cells, Eph/Ephrin signaling pathway, and the relationship between Eph/Ephrin signaling pathway and proliferation and differentiation of neural stem cells. However, the specific mechanism by which the Eph/Ephrin signaling pathway controls neural stem cell differentiation is not well understood.