二丁酰环磷腺苷钙联合芪苈强心胶囊治疗慢性心力衰竭患者的疗效观察

Effect observation of calcium dibutyryladenosine cyclophosphate combined with Qili Qiangxin Capsules on the treatment of patients with chronic heart failure

目的探讨二丁酰环磷腺苷钙联合芪苈强心胶囊治疗慢性心力衰竭的疗效和安全性。方法选取120例慢性心力衰竭患者,随机分为观察组(常规治疗+二丁酰环磷腺苷钙和芪苈强心胶囊)和对照组(常规治疗)。比较2组的临床疗效、心率、心功能分级、6 min步行距离(6MWD)、明尼苏达心力衰竭生活质量(QOL)评分、左室舒张末期内径(LVED)、左心室射血分数(LVEF)、N末端脑钠肽原(NT-proBNP)、不良反应等指标。结果治疗4周后,观察组总有效率显著高于对照组(P<0.05),2组患者的血浆NT-proBNP水平均显著降低,但观察组显著低于对照组(P<0.05)。观察组心率、LVEF、LVED、6MWD、心功能以及QOL等方面的改善均显著优于对照组(P<0.05)。2组的不良反应发生情况比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上加用二丁酰环磷腺苷钙及芪苈强心胶囊治疗慢性心力衰竭安全有效,可显著降低NT-proBNP水平,改善患者症状,提升心功能,提高生活质量。

Objective To explore the efficiency and safety of calcium dibutyryladenosine cyclophosphate combined with Qili Qiangxin Capsules in treating patients with chronic heart failure.Methods A total of 120 patients with chronic heart failure were selected and randomly divided into observation group(calcium dibutyacyladenosine cyclophosphate plus Qili Qiangxin Capsules plus standard treatments)and control group(standard treatments).The clinical efficacy,heart rate,cardiac function classification,6-minute walking distance(6MWD),quality of life by Minnesota heart failure(QOL),left ventricular end-diastolic diameter(LVED),left ventricular ejection fraction(LVEF),N-terminal brain natriuretic peptide(NT-proBNP),and adverse reactions were compared between the two groups.Results After 4 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05),the plasma NT-proBNP level in both groups significantly decreased,and the plasma NT-proBNP level in observation group was significantly lower than that in the control group(P<0.05).The improvements of heart rate,LVEF,LVED,6MWD,cardiac function and QOL in the observation group were significantly better than those in the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion On the basis of routine treatment,calcium dibutyryladenosine cyclophosphate combined with Qili Qiangxin Capsules is safe and effective in the treatment of patients with chronic heart failure,which can significantly reduce the level of NT-proBNP,improve the symptoms and cardiac function of patients,and improve the quality of life.