穗花牡荆文献研究及药性探讨

Literature Research and Discussion of Chinese Medicine Properties of Vitex agnus-castus L.

目的:基于外来植物药穗花牡荆(Vitex agnus castus L)的科学研究文献,结合中医药理论探讨穗花牡荆的中药药性,为穗花牡荆在我国的研究、配伍及临床应用提供理论基础。方法:选取中国知网、Web of Science(Wo S)核心合集(SCI)和Pub Med文献数据库并查阅穗花牡荆相关文献,筛选设计合理、信度较高、结论可靠的科学研究文献,以46篇临床研究文献为依据,126篇化学成分、药理研究文献为佐证,结合中医理论探讨穗花牡荆的中药药性。结果:初步推断穗花牡荆的中药药性为辛、甘,微寒,归肝、肾经;功能主治为疏肝解郁、填精益髓、强筋健骨,用于经前期综合征之烦躁易怒、乳房胀痛、头痛等,预防骨质疏松、促进骨折愈合。结论:概括归纳穗花牡荆的性味归经、功能主治及用法用量,赋予穗花牡荆明确的中药药性,为穗花牡荆与中药的配伍及临床应用奠定理论基础。

Objective:To provide the theoretical basis for the research,compatibility and clinical application of Vitex agnus-castus L.in China based on the scientific literature of Vitex agnus-castus L.and traditional Chinese medicine theory to explore the medicinal properties of it.Methods:After checking the related documents in CNKI,Web of science and Pubmed databases,the irrelevant and duplicate documents,accept documents which has rational design,high reliability,and reliable conclusions were selected out.The medicinal properties of Vitex agnus-castus L were studied combining its′clinical trials,chemical constituents researches,pharmacological researches and traditional Chinese medicine theory.Results:The preliminary inference of the traditional Chinese medicinal properties of Vitex agnus-castus L.were as follows:the property and flavor were pungent,sweet,slightly cold and belonging to liver and kidney;the function was soothing the liver to remove stagnancy of liver-qi,filling essence,strong sinews and bones.It could be used for the treatment of premenstrual syndrome irritability,emotional restlessness,breast tenderness,headache,etc.,and to prevent osteoporosis and promote fracture healing.Conclusion:Summarizing the characteristics of natures,tastes,guiding,function indications,usage and dosage,it will lay a theoretical foundation for the compatibility and clinical application of Vitex agnus-castus L..