烟酸和烟酰胺治疗血液透析患者高磷血症的研究进展

Research progress of niacin and nicotinamide on hyperphosphatemia in hemodialysis patients

慢性肾脏病(CKD)是全球公共健康问题之一。在中国,成年人CKD患病率高达10.8%。高磷血症是CKD患者常见的严重并发症之一,往往发生于终末期肾病(End stage renaldisease,ESRD)阶段。高磷血症也是CKD患者心血管事件(CVD)发生的高危因素,在血液透析(Hemodialysis,HD)患者中较为普遍,增加CKD患者死亡风险。目前,控制高磷血症通常需要联合低磷饮食、充分透析、降磷药物治疗。其中,磷酸盐结合剂在临床上运用较多。但近年来,大量研究表明烟酸和烟酰胺能有效降低血液透析患者血磷水平,本文就此研究进展作一综述。

Chronic kidney disease(CKD)is one of the worldwide public health problem.In China,the prevalence of CKD in adults is 10.8%.Hyperphosphatemia is a common complication of chronic kidney disease,especially in endstage renal disease.Hyperphosphatemia is a high risk factor for cardiovascular events(CVD).It is common in patients with Hemodialysis(HD)and increased the high mortality rate of CKD patients.The most rencet approach of controling hyperphosphstemia is combination of low phosphorus diet,adequate dialysis and medicine.Phosphorus binderis widely used in clinical practice.Now,Some studies have shown that niacin and nicotinamide effectively reduce serum phosphorous in hemodialysis patients.In this paper,it is reviewed.