HAART对AIDS合并HBV/HCV感染患儿CD4^+T细胞、病毒载量的影响

Effect of HAART on CD4^+T cell and viral load in children with AIDS combined with HBV/HCV infection

目的探讨高效抗逆转录病毒治疗(HAART)对AIDS合并HBV/HCV感染患儿CD4^+T细胞、病毒载量和肝功能的影响。方法选取2014年4月至2015年4月在该院接受治疗的单纯HIV感染患儿88例,分为A组;HIV合并HBV感染的患儿8例,分为B组;然后将HIV合并HCV感染的23例患儿分为C组。3组患儿全部接受HAART治疗,治疗时间为两年,比较3组患儿治疗前后肝功能、病毒载量以及CD4^+T细胞变化情况。结果治疗前,3组肝功能异常的患儿共计29例(24.79%),3组组间比较差异无统计学意义(P>0.05);治疗后,3组肝功能异常的患儿共计82例(70.09%),3组治疗前后比较差异有统计意义(P<0.05)。治疗前,3组患者的AIT、AST及TBIL水平比较差异无统计学意义(P>0.05);治疗后,3组患儿的AIT、AST及TBIL水平均明显升高,差异有统计学意义(P<0.05);且A组的ALT水平明显低于B组和C组,差异有统计学意义(P<0.05)。3组AST、TBIL水平比较无统计学意义(P>0.05)。治疗前,3组患儿的CD4^+T细胞及HIV RNA水平比较,差异有统计学意义(P<0.05);治疗后,3组患者的CD4^+T细胞水平均明显增高,HIV RNA水平均明显降低,,差异有统计学意义(P<0.05)。但3组患者组间比较差异无统计学意义(P>0.05)。结论高效抗逆转录病毒治疗AIDS合并HBV/HCV感染患儿,对患儿的肝功能存在不同差异,治疗后能明显升高CD4^+T细胞水平,降低病毒载量,对于AIDS合并HBV/HCV感染患儿均存在不同差异,在临床应用过程中应密切关注患儿的肝功能状况。

Objective To investigate the effect of high performance antiretroviral therapy on CD4^+T cells,viral load and liver function in children with AIDS combined with HBV/HCV infection.Methods The simple HIV from April 2014 to April 2015 in our hospital infection in 88 cases were divided into group A,8 cases of HIV patients with HBV infection was divided into B group,and 23 cases of HIV patients with HCV infection was divided into C group,three groups were all treated with HAART,after about two years treatment time,before and after treatment of liver function,viral load and CD4+T cell changes between the three groups were compared.Results Before treatment,the total of three groups of children with abnormal liver function was 29 cases(24.79%),and the three groups were not statistically significant(P﹥0.05).After treatment,the total of three groups of children with abnormal liver function were 82(70.09%),and the difference between the three groups was statistically significant(P﹤0.05).Before treatment,there was no significant difference in the levels of AIT,AST and TBIL between the three groups(P﹥0.05).After treatment,the levels of AIT,AST and TBIL in the three groups increased significantly(P﹤0.05).The data between the three groups were not statistically significant(P﹥0.05).Before treatment,there was no significant difference between the three groups of children with CD4+T cells and viral load(P﹥0.05);after treatment,the three groups of patients with CD4+T(P﹤0.05)cells increased,HIVRNA decreased significantly(P﹤0.05),the three groups had no statistically significant difference between the two groups of patients(P﹥0.05).Conclusion High-efficiency antiretroviral treatment in children with AIDS complicated with HBV/HCV infection,there are different differences in liver function of patients,after treatment can significantly increase the level of CD4+T cells,reduce viral load,AIDS combined with HBV/HCV infected children have different differences,the liver function should be paid close attention in clinical application.