TC/HDL-C比值及超敏C反应蛋白与糖尿病视网膜病变相关性研究

The correlation between TC/HDL-C ratio and hypersensitivity C reactive protein and diabetic retinopathy

目的探讨血脂组分异常及超敏C反应蛋白(hs-CRP)与糖尿病视网膜病变进展的相关性。方法对2015年7月至2017年7月该院内分泌科糖尿病住院患者进行眼底检查,通过眼底荧光素钠造影根据病变程度分为3组,未发现视网膜病变组(A组),视网膜病变非增殖期组(B组),视网膜病变增殖期组(C组),检测3组的血脂组分及血清hs-CRP水平,并计算总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)比值,用SAS9.4统计软件进行统计学处理。结果糖尿病视网膜病变患者TC/HDL-C比值及血清hs-CRP水平明显升高,3组的hs-CRP水平、TC/HDL-C比值分别与健康对照组比较,差异均有统计学意义(P<0.05);其中A组分别与B组、C组的hs-CRP水平,TC/HDL-C比值比较,差异均有统计学意义(P<0.05);B组和C组的hsCRP水平,TC/HDL-C比值比较差异无统计学意义(P>0.05)。采用线性相关性分析血清hs-CRP水平和TC/HDL-C比值,发现两者具有正向相关性,推测有正向协同作用。结论血清hs-CRP的检测对糖尿病视网膜病变的发生、病情评估及预后具有重要的临床应用价值;TC/HDL-C比值所反映的血脂组分异常也是评估糖尿病视网膜病变发生进展的一个重要的因素。

Objective To study the relationship between the abnormal blood fat components and the serum hypersensitivity C reaction protein concentration and the progression of diabetic retinopathy.Methods Fundus examination was carried out to inpatients in the Department of Endocrinology in the hospital from From July 2015 to July 2017.These patients were divided into three groups according to results of fluorescein sodium contrast:The non retinopathy group(group A),the non proliferative retinopathy group(group B),the retinopathy proliferative phase group(group C).The content of blood fat component and serum hypersensitivity C reaction protein in the experimental cases were measured,and the ratio of TC/HDL-C was calculated.The statistic software of SAS9.4 was used for statistical processing.Results The concentration of the serum hypersensitive C reaction protein in patients with diabetic retinopathy was significantly increased and the ratio of TC/HDL-C increased significantly(P﹤0.05).The hs-CRP concentration and TC/HDL-C ratio of the three study groups were compared with those of the healthy control group:the difference was statistically significant(P﹤0.05).Among them,the hs-CRP concentration and TC/HDL-C ratio of group A were compared with group B and group C respectively and the difference were statistically significant(P﹤0.05).There was no significant difference in hs-CRP concentration and TC/HDL-C ratio between group B and group C(P﹥0.05).Linear correlation analysis was used to analyze the concentration of serum hypersensitive C reaction protein and the ratio of TC/HDL-C.It was found that there was a positive correlation between them,and there was a positive synergistic effect.Conclusion The measurement of serum hypersensitive C reactive protein has important clinical value for the discovery,evaluation and prognosis of diabetic retinopathy.The abnormalities of the blood fat component reflected by the TC/HDL ratio are also an important factor in assessing the progression of diabetic retinopathy.