Hp抗原联合血清总唾液酸和胃黏膜Survivin检测对胃腺癌诊断的意义

The significance of Hp antigen combined with serum total sialic acid and gastric mucosal Survivin detection in the diagnosis of gastric adenocarcinoma

目的探讨Hp抗原联合血清总唾液酸和胃黏膜Survivin检测对胃腺癌诊断的意义。方法选取该院收治的90例胃腺癌(恶性肿瘤组)、90例消化系统良性疾病患者(良性疾病组)及同期入院体检的60例健康人(健康对照组)为研究对象。比较3组受试者Hp抗原、血清总唾液酸阳性检出率及胃黏膜Survivin的阳性率,并评估单独检测Hp抗原、血清总唾液酸及二者联合诊断胃腺癌的灵敏度与特异度。结果 Hp抗原、血清总唾液酸阳性率检测结果显示,恶性肿瘤组受试者明显高于良性疾病组以及健康对照组,良性疾病组明显高于健康对照组,3组受试者间比较差异具有统计学意义(P<0.05)。线性相关分析表明,Hp抗原、血清总唾液酸联合检测与胃黏膜Survivin检测的结果呈正相关(r=0.94,P<0.05)。Hp抗原、血清总唾液酸联合诊断胃腺癌的灵敏度为80.1%,明显高于单独检测其中一项,但特异度降低。结论 Hp抗原、血清总唾液酸联合检测与胃黏膜Survivin检测的结果呈正相关,其相关度较高,可以作为胃腺癌诊断的敏感指标。

Objective To explore the significance of Hp antigen combined with serum total sialic acid and gastric mucosal Survivin detection in the diagnosis of gastric adenocarcinoma.Methods Selected a hospital 90 cases of patients with gastric adenocarcinoma(malignant group)and 90 cases of the digestive system benign disease(benign disease group)and hospital check-up of 60 cases of healthy people(healthy control group)as the research object.Comparing the three groups of patients with Hp antigen,serum total sialic acid positive detection rate and the positive rate of Survivin in the gastric mucosa,and to assess individual detection of Hp antigen,serum total sialic acid and the two combined diagnostic sensitivity and specificity of gastric adenocarcinomas.Results Hp antigen,serum total sialic acid positive test results showed that the malignant tumor group were significantly higher than that of benign disease group and healthy control group,benign disease group obviously higher than that of healthy control group,difference between three groups of participants were statistically significant(P﹤0.05).The sensitivity of Hp antigen and serum total sialic acid combined in the diagnosis of digestive system was 80.1%,which was significantly higher than that of single test,but the specificity was reduced.Linear correlation analysis showed that there was a positive correlation between Hp antigen and serum total sialic acid and Survivin detection in gastric mucosa,and the correlation was high(r=0.94,P﹤0.05).Conclusion The combined detection of Hp antigen and total serum sialic acid is positively correlated with the results of Survivin detection in gastric mucosa,and has a high correlation.It can replace Survivin detection in gastric mucosa as a sensitive index for the diagnosis of gastric adenocarcinoma.