结直肠癌患者组织中CD39的表达与临床病理特征及预后的关系

Relationship between the expression of CD39 and clinicopathological features and prognosis in colorectal cancer

【目的】探讨结直肠癌(colorectal carcinoma,CRC)组织中CD39的表达与临床病理特征及患者预后的关系。【方法】选取2014年3月至2015年4月于我院经手术切除的CRC组织标本90例(CRC组),收集其癌旁组织标本作为对照组。采用免疫组化法检测CD39在CRC组织及癌旁组织中的表达情况,观察并分析其与患者临床病理特征的关系,采用Kaplan-Meier对CRC患者3年生存情况进行分析,采用Logistic多因素回归分析CD39表达的独立影响因素,Cox比例风险模型(cox proportionalhazards model,COX)比例风险回归分析CRC患者预后生存的独立危险因素。【结果】CRC组CD39蛋白阳性表达率高于对照组(P<0.05);CD39表达与淋巴结转移、肿瘤分期、组织分化程度及浸润深度相关(P<0.05);Kaplan-Meier生存曲线显示CD39阴性表达组无进展生存期、总生存期高于阳性表达组(P<0.05);Logistic多因素分析显示肿瘤分期、淋巴结转移与组织分化程度均为CD39阳性表达的独立影响因素;COX比例风险回归分析显示CD39阳性表达为CRC患者预后的独立危险因素。【结论】CD39在CRC组织中高表达并与患者临床病理特征密切相关,可用于预测患者预后。

【Objective】To explore the relationship between the expression of CD39 and clinicopathological features and prognosis in colorectal cancer (CRC).【Methods】A total of 90 colorectal carcinoma tissue samples were selected as the CRC group from March 2014 to April 2015, and the paracancerous tissue specimens were collected as the control group. Immunohistochemistry was used to detect the expression of CD39 in colorectal carcinoma tissues and adjacent tissues. The relationship between with the expression and clinicopathological characteristics was analyzed. Kaplan-Meier was used to analyze the 3-year survival of CRC patients. Logistic multivariate regression analysis was used to analyze the independent influence factors of CD39 expression and COX proportional hazards regression was used to analyze the independent survival risk factors for CRC patients.【Results】The positive expression rate of CD39 protein in the CRC group was higher than that in the control group (P<0.05). The CD39 expression was associated with lymph node metastasis, tumor stage, tissue differentiation and depth of invasion (P<0.05). Kaplan-Meier survival curve showed that PFS and OS in the CD39 negative expression group were higher than those in the positive expression group (P<0.05). Logistic multivariate analysis showed that tumor stage, lymph node metastasis and tissue differentiation were independent influencing factors of CD39 positive expression. COX proportional hazards regression analysis showed that CD39 positive expression was an independent risk factor for prognosis in CRC patients.【Conclusion】CD39 is highly expressed in CRC tissues and closely related to clinicopathological features of patients. Therefore, it can be used to predict the prognosis.