臭氧自体血回输治疗带状疱疹后神经痛的临床疗效及对血清IL-6 TNF-α的影响

The Clinical Efficacy of Ozone Autologous Blood Transfusion in the Treatment of Post-herpes Zoster Neuralgia and its Effect on Serum IL-6 and TNF-vaccine

目的:观察臭氧自体血回输对带状疱疹后神经痛的临床疗效以及对血清白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α的影响。方法:回顾分析90例带状疱疹后神经痛患者,根据治疗的方法分为对照组和研究组,对照组给予普瑞巴林治疗,研究组给予普瑞巴林联合臭氧自体血回输治疗。比较两组在治疗有效率、疼痛评分、血清IL-6、TNF-α的变化。结果:研究组治疗有效率为81.39%,明显优于对照组的72.09%。治疗后两组VAS评分、血清IL-6、TNF-α变化与治疗前有差异具有统计学意义,且研究组在治疗后VAS评分、血清IL-6、TNF-α明显低于对照组(P<0.05)。结论:臭氧自体血回输联合药物治疗带状疱疹后神经痛临床疗效确切,值得推荐使用,其机制与降低患者血清IL-6、TNF-α含量有关。

Objective:To observe the clinical effect of ozone autologous blood transfusion on post-herpes zoster neuralgia and its effect on serum IL-6 and TNF-α.Methods:Retrospective analysis was performed on 90 cases of post-herpetic neuralgia treated in our hospital,which were divided into control group and study group according to the treatment method.The control group was treated with prebahrain treatment and the study group was treated with prebahrain combined with ozone autologous blood transfusion.Changes in treatment efficiency,pain score,serum IL-6,TNF-α,were compared between the two groups.Results:The effective rate of treatment in the study group was 81.39%,which was significantly superior to 72.09%in the control group.Changes in VAS score,serum IL-6 and TNF-αlevel in the two groups after treatment were statistically significant compared with those before treatment,and VAS score,serum IL-6 and TNF-αwere significantly lower in the study group than in the control group(P<0.05).Conclusion:Ozone autologous blood transfusion combined with drug therapy is effective in treating neuralgia after herpes zoster.