健康体检人群血糖水平与血清CA199水平的相关性研究

The Relation between Plasma Glucose and Serum CA199 Levels in Physical Examination People

目的:探讨健康体检人群血糖水平与糖类抗原CA199的相关性研究。方法:资料选取于2017年1月至2018年1月在河北省某体检中心进行健康体检的40～80岁人群,共2868例,按CA199水平分为阴性组(<34U/mL)和阳性组(≥34U/mL),比较两组的临床资料有无差异,并比较不同血糖水平时各临床指标及CA199的变化。结果:CA199阳性组的HbA1c、FPG、AST、ALT较CA199阴性组升高(P<0.05)。两组性别、年龄、BMI、SBP、DBP、TG、TC、LDL-C、HDL-C、BUN、Scr、SUA、γ-GGT、Hcy、WBC、NEUT、LYM等比较,差异无统计学意义(P>0.05)。随着HbA1C的增高,CA199水平明显升高(P<0.01)。Pearson相关分析显示,CAl99水平与FPG(r=0.272,P <0.01)、Hb Alc(r=0.289,P <0.01)、AST(r=0.112,P<0.01)、ALT(r=0.087,P<0.05)呈正相关,多元logistic回归分析显示FBG、HbAlc与CAl99升高有关(OR=1.903,2.243,P=0.012,0.005)。结论:健康体检人群FPG、Hb A1c对血清CA199水平存在影响,血糖控制不佳与CA199升高有关。

Objective:To investigate the relationship between plasma glucose and serum CA199 levels in physical examination people.Methods:A total of 2868 people aged 40-80 years were enrolled retrospectively from one medical center for physical examination of Hebei.According to CA199 level,all people were divided into negative group(<34U/ml)and positive group(≥34U/ml).Clinical data were compared between the two groups.The kinds of clinical data and the change of CA199 were compared according to different level of plasma glucose.Results:Compare with CA199 negative group,the levels of HbA1c,FPG,AST and ALT(P<0.05)were significantly higher in CA199 positive group.The sex,age,BMI,SBP,DBP,TG,TC,LDL-C,HDL-C,BUN,Scr,SUA,γ-GGT,Hcy,WBC,NEUT,LYM between the two groups were no significant differences(P>0.05).With the increase of HbA1c,the levels of CA199 were significantly higher(P<0.01).Pearson analysis showed that the level of CA199 was positively correlated with FPG(r=0.272,P<0.01),HbA1c(r=0.289,P<0.01),AST(r=0.112,P<0.01),ALT(r=0.087,P<0.05).Multiple logistic regression analysis showed that FPG and HbA1c were associated with CA199(OR=1.903,2.243,P=0.012,0.005).Conclusion:The level of serum CA199 was affected by FPG and HbA1c in healthy people.Poor control of blood sugar was related to the increase of CA199.