LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中的调控作用

Regulation of LKB1-AMPKα-SIRT1 Signal Pathway in Lipid Metabolism in the Adipose Tissue of Dairy Cows

奶牛脂肪细胞体积和数目的不断增加会导致脂肪组织脂代谢的紊乱,引起一系列相关慢性疾病如Ⅱ型糖尿病、酮病、脂肪肝、高脂血症等的发生,LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中起着重要的调控作用。单磷酸腺苷活化蛋白激酶(AMPK)是比较保守的丝氨酸/苏氨酸激酶,在调节能量代谢中起着枢纽作用。肝激酶B1(LKB1)属于一种丝氨酸激酶,是AMPKα的上游激酶,可参与细胞内能量代谢等多种生物活动。沉默信息调节因子1(SIRT1)是一种NAD+依赖的组蛋白去乙酰化酶,可通过去乙酰化LKB1增加AMPKα的活性。就LKB1-AMPKα-SIRT1信号转导通路在奶牛脂肪组织脂代谢紊乱中的调控机制作一综述,旨在为下一步研究奶牛脂代谢相关信号通路调控机理提供依据。

The increasing volume and number of adipocyte leads to disorder of lipid metabolism in adipose tissue,which causes different chronic diseases such as type II diabetes,ketosis,fatty liver,and hyperlipidemia.The LKB1-AMPKα-SIRT1 signal pathway plays important regulating role in the lipid metabolism of dairy cows adipose tissue.AMPK as conservative serine/threonine kinase plays a pivotal role in the regulation of energy metabolism.LKB1(liver kinase B1)is a serine/threonine kinase,an upstream kinase of AMPKα,participates in various biological activities such as intracellular energy metabolism.Silencing information regulator factor 1(SIRT1),a kind of NAD^+-dependent histone deacetylase,can increase AMPKα activity by deactivating LKB1.This article reviews the regulation mechanisms of LKB1-AMPKα- SIRT1 signal transduction pathways in lipid metabolism of adipose tissue in dairy cows,aiming at providing a basis for further studying the regulating mechanisms of related signal pathways in the lipid metabolism of dairy cows.