保乳治疗乳腺癌患者临床病理特征与预后的相关性

Correlation between clinicopathological features and prognosis of breast cancer patients treated with breast-conserving therapy

目的分析行保乳治疗的乳腺癌患者临床、病理特征与预后的相关性。方法回顾性分析2010年1月至2012年12月于安徽医科大学第二附属医院接受保乳治疗的206例女性乳腺癌患者临床资料,总结患者的临床、病理特征。通过Kaplan-Meier单因素分析患者临床、病理特征(年龄、月经状态、病理类型、肿瘤大小、淋巴结状态、激素受体状况、Ki-67指数、HER-2表达状况、神经脉管浸润情况等因素)对预后的影响,对单因素分析差异有统计学意义的因素进行Cox回归分析。结果单因素分析显示,不同年龄患者5年生存率比较,差异无统计学意义(P> 0. 05),不同月经状态、淋巴结状态、Ki-67指数及神经脉管浸润差异有统计学意义(P <0. 05);多因素分析显示,月经状态、淋巴结状态及Ki-67指数与保乳治疗的预后具有相关性(P <0. 05)。结论保乳治疗的乳腺癌患者的年龄与预后无相关性。绝经、淋巴结转移、Ki-67指数是影响保乳治疗的乳腺癌患者预后独立影响因素。

Objective To analyze the clinicopathological features and their correlation with the prognosis of breast cancer patients treated with breast-conserving therapy.Methods A retrospective analysis was performed on 206 female breast cancer patients who underwent breast-conserving therapy from the Second Affiliated Hospital of Anhui Medical University from Jan 2010 to Dec 2012,and the clinicopathological features of the patients were summarized.Kaplan-Meier univariate analysis was used to analyze the influence of clinicopathological features(age,menstrual status,pathological type,tumor size,lymph node status,hormone receptor status,Ki-67 index,Her-2 expression status and neurovascular infiltration)on the prognosis of the patients.Cox regression multivariate survival analysis was employedto examine the factors with statistical significance in univariate analysis.Results Univariate analysis showed that there was no significant difference in the 5-year survival rate of patients of different age(P>0.05).There were significant differences in different menstrual status,lymph node status,Ki-67 index and neurovascular invasion(P<0.05).Multivariate analysis showed that menstrual status,lymph node status and Ki-67 index were correlated with the prognosis of breast-conserving therapy(P<0.05).Conclusion The age of breast cancer patients is not correlated to the prognosis of breast-conserving therapy.Menopause,lymph node metastasis and Ki-67 index are independent prognostic factors of breast cancer patients with breast-conserving therapy.