酒依赖共病双相情感障碍患者冲动攻击行为与5-HTR1B基因多态性关联分析

Association between the polymorphism of 5-hydroxy tryptamineta 1B receptor gene and impulsive aggression behavior in patients with comorbid alcohol dependency and bipolar disorder

目的探讨酒依赖共病双相情感障碍患者的冲动攻击行为与5-HTR1B rs6296基因多态性的关联,为酒依赖共病双相情感障碍患者冲动攻击行为导致病理生理改变机制的潜在遗传学差异的研究提供参考。方法采用病例对照研究,纳入符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)酒依赖共病双相情感障碍诊断标准的患者230例,依据修订版外显攻击行为量表(MOAS)评分分为有冲动攻击行为组(n=128)和无冲动攻击性行为组(n=102)。通过PCR直接测序法对rs6296基因多态性进行测定,并分析5-HTR1B rs6296基因多态性与酒依赖共病双相情感障碍患者冲动攻击行为的关联性。结果酒依赖共病双相情感障碍患者有冲动攻击行为组与无冲动攻击行为组rs6296位点的等位基因频率分布差异无统计学意义(χ~2=2.135,P>0.05);两组rs6296位点基因型分布差异无统计学意义(χ~2=2.771,P>0.05)。结论酒依赖共病双相情感障碍患者冲动攻击行为与5-HTR1B rs6296基因多态性无关联。

Objective To investigate the correlation between impulsive aggression behavior and 5-hydroxy tryptamine 1B receptor(5-HTR1B)gene polymorphisms in patients with comorbid alcohol dependency and bipolar disorder,and to provide references for understanding the potential genetic differences in the mechanism of pathophysiological changes caused by impulsive aggression of patients with comorbid alcohol dependency and bipolar disorder.Methods A total of 230 patients who were diagnosis with alcohol dependency cormobid with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders,fourth edition(DSM-IV)were recruited.All patients were divided into the impulsive aggression group(n=128)and non-impulsive aggressive behavior group(n=102)according to the Modified Overt Aggression Scale(MOAS)score.The polymorphisms of rs6296 were identified by PCR direct sequencing,in addition the relationship between the differences of 5-HTR1B rs6296 polymorphisms and impulsive aggression were analyzed.Results There was no significant difference between the genotype of rs6296 in the impulsive aggression group(n=128)and the non-impulsive aggressive behavior group(χ^2=2.135,P>0.05).No significant difference was found between the allele frequency of rs6296 in the two groups(χ^2=2.771,P>0.05).Conclusion There was no correlation between impulsive aggression behavior and 5-HTR1B rs6296 polymorphisms in patients with comorbid alcohol dependency and bipolar disorder.